IMMUNORADIOMETRIC ASSAYS Meaning and
Definition
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Immunoradiometric assays (IRMA) are a highly sensitive type of immunoassay technique used to measure and quantify specific substances, such as hormones or proteins, in biological samples. It combines the principles of radioimmunoassays (RIA) and immunometric assays to provide accurate and precise measurements of the analyte of interest.
The IRMA method relies on the use of specific antibodies that bind to the target analyte, along with a radioactive label, typically iodine-125, attached to either the antibody or the analyte itself. The radioactive label serves as a detection marker, allowing for the quantification of the analyte concentration.
The assay begins by incubating the biological sample, containing the analyte of interest, with a mixture of labeled and unlabeled antibodies. Due to the high affinity and specificity of the antibodies, they form a complex with the analyte, resulting in a measurable signal. The unbound components are then removed, and the remaining complex is measured using a gamma counter to detect the radioactivity.
IRMA offers several advantages over other immunoassay techniques. It exhibits high sensitivity, low detection limits, and wide dynamic range, making it suitable for the analysis of substances present in low concentrations. It also has excellent precision and accuracy, making it a reliable method for clinical and research applications.
Overall, immunoradiometric assays provide a powerful tool for the quantification of specific analytes in biological samples, facilitating important medical diagnoses, therapeutic monitoring, and research investigations.
Common Misspellings for IMMUNORADIOMETRIC ASSAYS
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Etymology of IMMUNORADIOMETRIC ASSAYS
The word "Immunoradiometric Assays" can be broken down into its constituent parts to understand its etymology:
1. "Immuno-": This prefix comes from the Latin word "immunis", which means "free" or "exempt". In this context, it refers to the immune system.
2. "Radio-": This prefix stems from "radius", a Latin word meaning "ray" or "beam". It is used to denote the involvement of radioactive materials or radiation in a process.
3. "Metric": Derived from the Greek word "metron", which means "measure". It indicates the quantification or measurement aspect of the term.
4. "Assays": This term originates from Old French "assai", which means "trial" or "test". It refers to a procedure used to assess or analyze the presence or concentration of a substance, usually in a biological sample.
