IMMUNOBLASTIC LYMPHADENOPATHY Meaning and
Definition
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Immunoblastic lymphadenopathy, also known as Castleman's disease, is a rare lymphoproliferative disorder characterized by abnormal growth of lymphoid tissue in one or multiple lymph nodes. It primarily affects the lymph nodes located in the chest, abdomen, and neck regions. The condition is named after Dr. Benjamin Castleman, who first described it in the 1950s.
Immunoblastic lymphadenopathy is classified into two variants: unicentric and multicentric. Unicentric Castleman's disease involves the enlargement of a single lymph node or a group of lymph nodes, whereas multicentric Castleman's disease involves the enlargement of multiple lymph nodes throughout the body.
The disease is characterized by the excessive production of a specific type of immune cells called B-cells. It is often associated with flu-like symptoms such as fever, fatigue, night sweats, and weight loss. The affected lymph nodes may become enlarged, firm, and tender to touch.
Immunoblastic lymphadenopathy is not directly linked to any specific cause, but it is believed to have an association with a viral infection, particularly human herpesvirus-8 (HHV-8). It is more common in individuals with compromised immune systems, including those with HIV/AIDS. Diagnosis typically involves a combination of physical examination, imaging tests, and biopsy of the affected lymph nodes.
Treatment options for immunoblastic lymphadenopathy include surgical removal of the affected lymph nodes, radiation therapy, and medications such as corticosteroids and immune modulators. In multicentric Castleman's disease, targeted therapies that inhibit specific pathways involved in B-cell overactivity, such as monoclonal antibodies, may be used. The prognosis varies depending on the type and stage of the disease, ranging from favorable in unicentric Castle
Common Misspellings for IMMUNOBLASTIC LYMPHADENOPATHY
- ummunoblastic lymphadenopathy
- jmmunoblastic lymphadenopathy
- kmmunoblastic lymphadenopathy
- ommunoblastic lymphadenopathy
- 9mmunoblastic lymphadenopathy
- 8mmunoblastic lymphadenopathy
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- ijmunoblastic lymphadenopathy
- imnunoblastic lymphadenopathy
- imkunoblastic lymphadenopathy
- imjunoblastic lymphadenopathy
- immynoblastic lymphadenopathy
- immhnoblastic lymphadenopathy
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- imm8noblastic lymphadenopathy
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- immuboblastic lymphadenopathy
- immumoblastic lymphadenopathy
Etymology of IMMUNOBLASTIC LYMPHADENOPATHY
The term "Immunoblastic Lymphadenopathy" is a medical term used to describe a condition involving enlarged lymph nodes characterized by the presence of immunoblasts. The etymology of this term can be broken down as follows:
1. Immuno-: This prefix is derived from the Latin word "immunis" meaning "exempt" or "protected". In medical terminology, it is used to refer to the immune system or immunity.
2. -blast: This suffix is derived from the Greek word "blastos" meaning "germ" or "bud". In medical terminology, it is used to refer to an immature or developing cell.
