HYDROXYMETHYLGLUTARYL COA SYNTHASE Meaning and
Definition
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Hydroxymethylglutaryl CoA synthase is an enzyme involved in the biochemical pathway of cholesterol synthesis, specifically in the mevalonate pathway. It is a key enzyme responsible for catalyzing the condensation reaction between acetyl-CoA and acetoacetyl-CoA to form hydroxymethylglutaryl CoA (HMG-CoA), an intermediate in the synthesis of cholesterol and other isoprenoid compounds.
HMG-CoA synthase plays a vital role in regulating cholesterol levels in the body. It is primarily located in the cytoplasm of liver cells and is tightly regulated at both the transcriptional and post-translational level. The activity of HMG-CoA synthase is influenced by various factors, including hormones such as insulin, glucagon, and thyroid hormones, as well as dietary factors.
Defects or mutations in the gene encoding HMG-CoA synthase can lead to a rare inherited disorder known as HMG-CoA synthase deficiency. This condition is characterized by a reduced or absent activity of the enzyme, resulting in impaired cholesterol synthesis and accumulation of toxic metabolites. It is associated with symptoms such as low blood sugar levels, muscle weakness, and recurrent episodes of vomiting.
In addition to its role in cholesterol synthesis, HMG-CoA synthase is also involved in the biosynthesis of other important molecules such as coenzyme Q10, dolichol, and isoprenoids involved in protein prenylation. The inhibition of HMG-CoA synthase by certain medications, such as statins, is a widely-used strategy to lower blood cholesterol levels and reduce the risk of cardiovascular diseases.
Common Misspellings for HYDROXYMETHYLGLUTARYL COA SYNTHASE
- hydroxymeth ylglutaryl coa synthase
- hydroxymethy lglutaryl coa synthase
- hydroxymethyl glutaryl coa synthase
- hydroxymethylg lutaryl coa synthase
- hydroxymethylgl utaryl coa synthase
- hydroxymethylglu taryl coa synthase
- hydroxymethylglut aryl coa synthase
- hydroxymethylgluta ryl coa synthase
- hydroxymethylglutar yl coa synthase
- hydroxymethylglutary l coa synthase
- hydroxymethylglutaryl c oa synthase
- hydroxymethylglutaryl co a synthase
- hydroxymethylglutaryl coa s ynthase
- hydroxymethylglutaryl coa sy nthase
- hydroxymethylglutaryl coa syn thase
- hydroxymethylglutaryl coa synt hase
- hydroxymethylglutaryl coa synth ase
- hydroxymethylglutaryl coa syntha se
- hydroxymethylglutaryl coa synthas e
