HURST SYNDROME Meaning and
Definition
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Hurst Syndrome, also known as congenital digital clubbing or digital clubbing syndrome, is a rare inherited disorder characterized by the abnormal enlargement of the tissues at the ends of the fingers and toes. This condition leads to the appearance of bulbous, rounded finger and toe tips, often described as "drumstick" or "club-like" deformities.
Individuals with Hurst Syndrome typically exhibit progressive changes in the nails as well, including increased curvature, thickening, and softening. These changes may cause the nails to appear abnormally shaped, referred to as "watch-glass" deformities. Additionally, affected individuals may experience excessive sweating of the fingers and toes.
The exact cause of Hurst Syndrome remains unknown. However, it is known to have a genetic basis, often inherited in an autosomal dominant manner. Mutations in the HPGD gene have been identified in some individuals with this condition, causing abnormal functioning of the prostaglandin D2 (PGD2) pathway and subsequent tissue growth abnormalities.
The physical deformities associated with Hurst Syndrome are typically present from birth or become noticeable during early childhood. Although the condition is generally non-life-threatening, it can impact an individual's quality of life by causing functional difficulties, such as impaired dexterity or discomfort while wearing shoes. There are currently no curative treatments for Hurst Syndrome, but management focuses on addressing symptoms and improving function.
Common Misspellings for HURST SYNDROME
- gurst syndrome
- burst syndrome
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- jurst syndrome
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- hyrst syndrome
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- hjrst syndrome
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- h8rst syndrome
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- huest syndrome
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- hufst syndrome
- hutst syndrome
- hu5st syndrome
- hu4st syndrome
- hurat syndrome
- hurzt syndrome
