HUMAN TUMOR CELL LINE Meaning and
Definition
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A human tumor cell line refers to a group of cells derived from a tumor in a human being that can be propagated in a laboratory setting under specific conditions. These cell lines serve as valuable tools for studying human cancer biology, as they provide a renewable supply of cells that closely mimic certain characteristics of actual tumors.
Typically, human tumor cell lines are established by extracting cells from a patient's tumor through a biopsy or surgical procedure. These cells are then cultured in a laboratory dish and provided with the necessary nutrients and growth factors to promote their proliferation. Over time, these cells adapt to the artificial environment in the laboratory and become immortalized, which means they can indefinitely multiply without undergoing senescence or cell death.
Human tumor cell lines are extensively utilized in cancer research to investigate various aspects of tumor biology, including the effects of potential therapeutic agents, mechanisms of drug resistance, and the molecular pathways involved in tumor progression. Researchers can study the growth patterns, genetic alterations, and responses to different treatments of these cell lines, which can provide insights into the behavior and characteristics of human tumors.
It is important to note that each human tumor cell line represents a specific type or subtype of cancer, as their properties may differ depending on the tissue of origin and the genetic alterations present in the original tumor. Consequently, it is crucial for researchers to carefully select and characterize cell lines that best represent the cancer type they seek to study.
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