HTH MOTIFS Meaning and
Definition
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HTH motifs, short for Helix-Turn-Helix motifs, are structural motifs that are found in a class of DNA-binding proteins known as transcription factors. These motifs play a crucial role in the regulation of gene expression by binding to specific DNA sequences.
The HTH motif consists of two α-helices connected by a short turn region. The first helix is referred to as the recognition helix, as it makes direct contact with the DNA backbone. The second helix forms a scaffold stabilizing the motif. Together, these helices create a structure resembling a hairpin or two adjacent helices.
HTH motifs are highly conserved across various organisms, indicating their functional significance. They are involved in the recognition of short DNA sequences, particularly those found within promoter regions, and facilitate the binding of transcription factors to these sequences.
The recognition of DNA by HTH motifs is primarily mediated through hydrogen bonding and hydrophobic interactions. The specific amino acid residues present within the recognition helix dictate the affinity and specificity of DNA binding. Variations in the amino acid composition of the recognition helix give rise to a diverse range of HTH motifs with different DNA-binding preferences.
Overall, the HTH motif is a vital structural component of transcription factors, enabling them to interact with DNA and play a crucial role in regulating gene expression.
Common Misspellings for HTH MOTIFS
- gth motifs
- bth motifs
- nth motifs
- jth motifs
- uth motifs
- yth motifs
- hrh motifs
- hfh motifs
- hgh motifs
- hyh motifs
- h6h motifs
- h5h motifs
- htg motifs
- htb motifs
- htn motifs
- htj motifs
- htu motifs
- hty motifs
- hth notifs
- hth kotifs
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