HTH MOTIF Meaning and
Definition
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HTH Motif refers to a specific sequence of amino acids that is commonly found in proteins involved in DNA binding and protein-ligand interactions. The term "HTH" stands for helix-turn-helix, which describes the secondary structure present in proteins containing this motif.
The HTH Motif consists of two alpha helices connected by a turn or loop region. The first helix, known as the recognition helix, is responsible for directly contacting the DNA or ligand molecule. This helix fits into the major groove of the DNA or interacts with the ligand to facilitate various biological processes, such as gene regulation, DNA replication, and DNA repair. The second helix provides stability to the overall structure.
The HTH Motif is highly conserved across many different species, highlighting its functional importance in biological systems. It is often found in transcription factors, which are proteins that regulate gene expression by binding to specific DNA sequences. Through the HTH Motif, transcription factors are able to recognize and bind to target DNA sequences, leading to the activation or repression of gene transcription.
Due to its structural characteristics and versatile functional properties, proteins containing the HTH Motif are involved in a wide range of biological processes, making it a crucial element in understanding molecular interactions and signaling pathways in cells.
Common Misspellings for HTH MOTIF
- gth motif
- bth motif
- nth motif
- jth motif
- uth motif
- yth motif
- hrh motif
- hfh motif
- hgh motif
- hyh motif
- h6h motif
- h5h motif
- htg motif
- htb motif
- htn motif
- htj motif
- htu motif
- hty motif
- hth notif
- hth kotif
Etymology of HTH MOTIF
The acronym "HTH" stands for "Hedgehog Turn Helix", while "motif" generally refers to a recognizable pattern. In molecular biology and genetics, the HTH motif refers to a specific structural pattern found in DNA-binding proteins. The term "HTH motif" likely originated from the observation of this particular repetitive pattern within the amino acid sequence of these DNA-binding proteins.
