HOMOSERINE DEHYDROGENASE Meaning and
Definition
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Homoserine dehydrogenase (HSD) is an enzyme involved in the biosynthesis of amino acids, specifically in the conversion of homoserine to aspartic acid. This enzyme plays a crucial role in the microbial metabolism of various amino acids such as methionine, threonine, and lysine.
Homoserine dehydrogenase is a key enzyme in the aspartic acid pathway, which is one of the two major pathways for the biosynthesis of this essential amino acid in microorganisms. It catalyzes the NAD(P)-dependent oxidation of homoserine, forming α-ketobutyrate and NAD(P)H in the process. This reaction is reversible, and homoserine dehydrogenase can also function as a reductase, converting α-ketobutyrate back to homoserine.
The activity of homoserine dehydrogenase is regulated by various factors, including feedback inhibition by the end product of the pathway, aspartic acid. This mechanism ensures that the production of aspartic acid is tightly regulated and prevents its overproduction.
Homoserine dehydrogenase is found in various organisms, such as bacteria, fungi, and plants. In bacteria, it is often encoded by the hom gene, while in plants and fungi, it is encoded by the thrA gene. The characterization and study of homoserine dehydrogenase have significant implications in understanding the metabolism and regulation of amino acid biosynthesis pathways, as well as their potential applications in industrial biotechnology and drug development.
Common Misspellings for HOMOSERINE DEHYDROGENASE
- gomoserine dehydrogenase
- bomoserine dehydrogenase
- nomoserine dehydrogenase
- jomoserine dehydrogenase
- uomoserine dehydrogenase
- yomoserine dehydrogenase
- himoserine dehydrogenase
- hkmoserine dehydrogenase
- hlmoserine dehydrogenase
- hpmoserine dehydrogenase
- h0moserine dehydrogenase
- h9moserine dehydrogenase
- honoserine dehydrogenase
- hokoserine dehydrogenase
- hojoserine dehydrogenase
- homiserine dehydrogenase
- homkserine dehydrogenase
- homlserine dehydrogenase
- hompserine dehydrogenase
- hom0serine dehydrogenase
Etymology of HOMOSERINE DEHYDROGENASE
The word "Homoserine Dehydrogenase" is derived from several components:
1. "Homo-" comes from the Greek word "homoios", meaning "same" or "similar". In scientific terminology, it is used to indicate something that is similar or related to another substance or structure.
2. "Serine" is a type of amino acid, which is one of the building blocks of proteins. It is named after the Latin word "sericum", meaning "silk", as it was first identified in silk protein.
3. "Dehydrogenase" is a suffix commonly used in biochemistry to describe enzymes that catalyze the removal of hydrogen atoms from molecules. It is derived from the Greek words "de" meaning "remove" and "hydor" meaning "water".
