HOMOSERINE DEHYDRATASE Meaning and
Definition
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Homoserine dehydratase, also known as homoserine dehydratase I or threonine synthase, is an enzyme that plays a crucial role in the biosynthesis of the essential amino acid, threonine. It catalyzes the conversion of L-homoserine, an intermediate in the metabolic pathway, into L-aspartate-beta-semialdehyde.
The enzyme is a member of the lyase family and is found in bacteria, plants, and fungi. It is a pyridoxal phosphate (PLP)-dependent enzyme, meaning it requires the cofactor PLP, derived from vitamin B6, for its catalytic activity. The cofactor PLP is essential for the binding and stabilization of reaction intermediates during catalysis.
The reaction mechanism of homoserine dehydratase involves the elimination of water from L-homoserine to form a double bond between the alpha and beta carbons. This reaction is followed by tautomerization to generate L-aspartate-beta-semialdehyde. The product, L-aspartate-beta-semialdehyde, is then further converted into threonine via subsequent enzymatic reactions in the metabolic pathway.
Threonine is an amino acid necessary for protein synthesis and also serves as a precursor for the biosynthesis of other important compounds such as pyridoxine (vitamin B6). Therefore, the activity of homoserine dehydratase is not only crucial for the synthesis of threonine but also for the overall metabolism of organisms.
Common Misspellings for HOMOSERINE DEHYDRATASE
- gomoserine dehydratase
- bomoserine dehydratase
- nomoserine dehydratase
- jomoserine dehydratase
- uomoserine dehydratase
- yomoserine dehydratase
- himoserine dehydratase
- hkmoserine dehydratase
- hlmoserine dehydratase
- hpmoserine dehydratase
- h0moserine dehydratase
- h9moserine dehydratase
- honoserine dehydratase
- hokoserine dehydratase
- hojoserine dehydratase
- homiserine dehydratase
- homkserine dehydratase
- homlserine dehydratase
- hompserine dehydratase
- hom0serine dehydratase
Etymology of HOMOSERINE DEHYDRATASE
The word "Homoserine Dehydratase" has its etymology rooted in the combination of different terms.
1. Homoserine: It comes from the combination of two components:
- Homo-: Derived from the Greek word "homos", meaning "same" or "alike". In scientific contexts, it often denotes similarity or sameness.
- Serine: Referring to an amino acid called serine, which is an essential building block of proteins.
2. Dehydratase: Derived from the combination of two components:
- De-: A prefix indicating reversal or removal.
- Hydratase: Derived from the word "hydrate", referring to the addition of water. In biochemistry, the term "hydratase" is used to describe enzymes that catalyze the addition or removal of water during a chemical reaction.
