HISTONE LYSINE METHYLTRANSFERASE Meaning and
Definition
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Histone Lysine Methyltransferase is an enzyme responsible for adding methyl groups to specific lysine residues on histone proteins. Histones are highly conserved proteins that play a crucial role in organizing and condensing DNA into a highly compact structure known as chromatin. Methylation of histones is a post-translational modification that regulates gene expression and other cellular processes.
Histone Lysine Methyltransferases are a diverse group of enzymes that catalyze the transfer of a methyl group from the methyl donor S-adenosyl-L-methionine (SAM) to the lysine residue of a histone protein. This enzymatic reaction leads to the introduction of a methyl group onto the nitrogen atom of the lysine side chain. Depending on the specific lysine residue targeted and the number of methyl groups added, this modification can have different functional consequences.
Histone Lysine Methyltransferases are classified into different subfamilies based on their conserved catalytic domains and substrate specificity. They include enzymes such as enhancer of zest-containing proteins (EZH), SET-domain-containing proteins, and the DOT1-like family. Each subfamily has distinct targets and prefers specific lysine residues for methylation.
The methylation patterns introduced by Histone Lysine Methyltransferases are dynamically regulated and can have profound effects on gene expression and cellular processes. Depending on the site and extent of methylation, it can either promote or repress gene transcription. Additionally, histone methylation can serve as a docking site for other proteins that recognize and interpret these modifications, leading to the establishment of specific chromatin states and the regulation of cellular functions such as cell proliferation, differentiation, and development.
Common Misspellings for HISTONE LYSINE METHYLTRANSFERASE
- gistone lysine methyltransferase
- bistone lysine methyltransferase
- nistone lysine methyltransferase
- jistone lysine methyltransferase
- uistone lysine methyltransferase
- yistone lysine methyltransferase
- hustone lysine methyltransferase
- hjstone lysine methyltransferase
- hkstone lysine methyltransferase
- hostone lysine methyltransferase
- h9stone lysine methyltransferase
- h8stone lysine methyltransferase
- hiatone lysine methyltransferase
- hiztone lysine methyltransferase
- hixtone lysine methyltransferase
- hidtone lysine methyltransferase
- hietone lysine methyltransferase
- hiwtone lysine methyltransferase
- hisrone lysine methyltransferase
- hisfone lysine methyltransferase
