Herpesvirales, also known as herpesviruses, are a large and diverse order of viruses that primarily infect vertebrates, including humans. This taxonomic order includes the family Herpesviridae, which is further divided into three subfamilies: Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae. Herpesvirales are characterized by their ability to establish lifelong latent infections in their hosts, which means that they can remain in a dormant state within the body without causing any symptoms but can reactivate and cause disease under certain circumstances.
These viruses have complex structures and contain double-stranded DNA genomes enclosed within an icosahedral protein capsid and surrounded by a lipid envelope. They are named after the characteristic herpetic lesions they cause, such as cold sores and genital herpes. However, herpesvirales can also cause a wide range of other diseases, including chickenpox (caused by Varicella-zoster virus), infectious mononucleosis (caused by Epstein-Barr virus), and some types of cancer (e.g., Kaposi's sarcoma, associated with Human herpesvirus 8).
Herpesviruses are highly contagious and are transmitted through direct contact with infectious body fluids or secretions. After initial infection, the viruses can spread to different tissues and organs, causing varied symptoms depending on the specific virus involved. Treatment usually involves antiviral medication to reduce the severity and duration of symptoms, but there is currently no cure for herpesvirales infections.
The term "herpesvirales" has its etymology rooted in the name of the family of viruses called Herpesviridae, of which herpesvirales is the taxonomic order. The word "herpes" has ancient Greek origins, derived from the Greek word "herpein", meaning "to creep or crawl". This term was initially used to describe the symptoms of the herpes simplex virus, characterized by its tendency to cause recurring skin eruptions. The suffix "-virales" is derived from the Latin word "virus", meaning "slimy liquid" or "poison", and is commonly used in virology to indicate an order of viruses. Therefore, "herpesvirales" essentially refers to the taxonomic order of viruses that share characteristics similar to the herpes simplex virus.