How Do You Spell HATU?
Pronunciation: [hˈɑːtuː] (IPA) 
Correct spelling for the English word "HATU" is [hˈɑːtuː], [hˈɑːtuː], [h_ˈɑː_t_uː] (IPA phonetic alphabet).
Pronunciation: [hˈɑːtuː] (IPA)
Correct spelling for the English word "HATU" is [hˈɑːtuː], [hˈɑːtuː], [h_ˈɑː_t_uː] (IPA phonetic alphabet).
HATU is an acronym that stands for 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. It is a chemical reagent used in organic synthesis and peptide chemistry. The compound is a carbodiimide derivative, which means it contains a central carbon atom doubly bonded to two nitrogen atoms with one nitrogen atom also being bonded to an alkyl group.
HATU is primarily employed as a coupling reagent in the formation of amide bonds. It promotes the coupling reaction between an amine and a carboxylic acid, leading to the formation of an amide bond. This reaction is widely used in the synthesis of peptides, where amino acids are linked together to form a peptide chain.
HATU is favored over other carbodiimide coupling agents due to its high reactivity and efficiency. It has excellent solubility in common organic solvents, enhancing its applicability in various synthetic procedures. Additionally, it offers ease of handling and is less prone to side reactions, resulting in cleaner reaction products.
The widespread use of HATU in peptide chemistry and organic synthesis has made it a valuable tool for researchers in the field. Its strong coupling ability and compatibility with diverse reaction conditions have contributed to its popularity and widespread adoption.
