GTP PHOSPHOHYDROLASE Meaning and
Definition
-
GTP phosphohydrolase refers to a class of enzymes involved in the hydrolysis or breakdown of guanosine triphosphate (GTP) molecules. GTP is a nucleotide similar to adenosine triphosphate (ATP) and is utilized as an energy source in various cellular processes. GTP phosphohydrolases play a fundamental role in regulating GTP-dependent signal transduction pathways and cellular functions.
The primary function of GTP phosphohydrolases is to catalyze the hydrolysis reaction of GTP, converting it into guanosine diphosphate (GDP) and inorganic phosphate (Pi). This reaction releases energy that can be harnessed by the cell to perform work and drive essential biological processes. GTP phosphohydrolases are often referred to as GTPases, and they belong to a larger class of enzymes known as hydrolases.
GTP phosphohydrolases are found throughout all living organisms, from bacteria to humans, and they are critical for numerous cellular functions. They act as molecular switches, controlling processes such as cell cycle progression, protein synthesis, cellular transport, signal transduction, and protein trafficking. These enzymes also regulate the activity of various GTP-binding proteins, including G-proteins and GTPases associated with vesicular trafficking.
Dysregulation or malfunction of GTP phosphohydrolases can have significant consequences for cellular homeostasis and can contribute to the development of various diseases, including cancer, neurological disorders, and immune dysfunction. Therefore, understanding the structure, mechanism, and regulation of GTP phosphohydrolases is of great importance in biomedical research, as it provides insights into cellular function and potential therapeutic targets.
Common Misspellings for GTP PHOSPHOHYDROLASE
- ftp phosphohydrolase
- vtp phosphohydrolase
- btp phosphohydrolase
- htp phosphohydrolase
- ytp phosphohydrolase
- ttp phosphohydrolase
- grp phosphohydrolase
- gfp phosphohydrolase
- ggp phosphohydrolase
- gyp phosphohydrolase
- g6p phosphohydrolase
- g5p phosphohydrolase
- gto phosphohydrolase
- gtl phosphohydrolase
- gt- phosphohydrolase
- gt0 phosphohydrolase
- gtp ohosphohydrolase
- gtp lhosphohydrolase
- gtp -hosphohydrolase
- gtp 0hosphohydrolase
Etymology of GTP PHOSPHOHYDROLASE
The term "GTP" in "GTP Phosphohydrolase" stands for guanosine triphosphate, which is a nucleotide involved in energy transfer in cells. "Phosphohydrolase" refers to an enzyme that catalyzes the hydrolysis of a phosphate bond. Therefore, "GTP Phosphohydrolase" refers to an enzyme that specifically hydrolyzes GTP.
The etymology of "guanosine" can be traced back to the late 19th century when Friedrich Miescher isolated a substance from nuclein, which he named "guanine". Guanine is derived from a combination of the Greek word "gennan", meaning "to produce" or "to generate", and its chemical compound "guanine".
