How Do You Spell GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE?

Pronunciation: [ɡlˈa͡ɪsɪnˌama͡ɪd ɹˈɪbənjˌuːklɪˌɒta͡ɪd fˈɔːmɪltɹɐnsfˌɜːɹe͡ɪz] (IPA)

The spelling of "glycinamide ribonucleotide formyltransferase" is complex due to the long string of specialized scientific terminology incorporated into the word. The phonetic transcription is /ɡlaɪˌsɪnəˌmaɪd ˌraɪbəˈnuːkliəˌtaɪd ˌfɔːmɪlˈtrænsfɜːreɪs/. This enzyme is involved in the synthesis of purine nucleotides in humans and is crucial for maintaining physiological balance within the body. While it may be difficult to spell, this word represents crucial concepts within the field of biochemistry.

Meaning and Definition
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GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE Meaning and Definition

  1. Glycinamide ribonucleotide formyltransferase is an enzyme that plays a crucial role in the biosynthesis of purine nucleotides, which are essential building blocks of DNA and RNA in living organisms. Specifically, this enzyme is involved in the transformation of glycinamide ribonucleotide (GAR) into formylglycinamide ribonucleotide (FGAR).

    Glycinamide ribonucleotide formyltransferase is a member of the transferase family of enzymes and is primarily found in bacteria, fungi, and plants. Its catalytic function involves the transfer of a formyl group from a molecule called 10-formyltetrahydrofolate (10-CHO-THF) to GAR. This formylation process is a vital step in the de novo synthesis of purine nucleotides.

    This enzyme's activity is regulated by various factors, including feedback inhibition by end products of the purine biosynthesis pathway, such as adenosine monophosphate (AMP) and guanosine monophosphate (GMP). Additionally, the enzyme's expression and activity can be influenced by other biochemical pathways and regulatory mechanisms within the cell.

    Due to its involvement in purine nucleotide synthesis, glycinamide ribonucleotide formyltransferase is an important target for drug development. Inhibitors of this enzyme can potentially impact the growth and survival of pathogens, making it a potential therapeutic target for the treatment of certain diseases.