GLOBOID LEUKODYSTROPHY Meaning and
Definition
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Globoid Leukodystrophy, also known as Krabbe disease, is a rare and progressive genetic disorder that affects the nervous system, specifically the myelin sheath, which is the protective covering surrounding nerve cells. It is classified as a leukodystrophy because it primarily impacts the white matter of the brain and spinal cord.
In Globoid Leukodystrophy, a deficient enzyme called galactocerebrosidase (GALC) leads to the accumulation of a particular type of fat called galactosylceramide in the brain, nerve cells, and other tissues. This buildup of galactosylceramide results in the destruction of the myelin sheath and causes widespread damage to nerve cells.
Symptoms of Globoid Leukodystrophy usually appear within the first six months of life and vary widely in severity. They may include irritability, muscle weakness, loss of muscle tone, feeding difficulties, vision loss, seizures, and developmental delay. As the disease progresses, affected individuals may experience further deterioration in motor skills, loss of hearing, and cognitive decline.
The prognosis for Globoid Leukodystrophy is generally poor, with most individuals experiencing a rapid and severe decline in health. The disease typically leads to premature death, often within the first two years of life. However, there are different forms of this condition, some of which may have a milder progression and later onset.
Currently, there is no cure for Globoid Leukodystrophy, and treatment primarily focuses on managing the symptoms and providing supportive care. This may involve physical therapy, medications to manage symptoms such as seizures or pain, and a multidisciplinary approach involving specialists in various areas, including neurology, genetics, and palliative care. Research efforts continue
Common Misspellings for GLOBOID LEUKODYSTROPHY
- floboid leukodystrophy
- vloboid leukodystrophy
- bloboid leukodystrophy
- hloboid leukodystrophy
- yloboid leukodystrophy
- tloboid leukodystrophy
- gkoboid leukodystrophy
- gpoboid leukodystrophy
- gooboid leukodystrophy
- gliboid leukodystrophy
- glkboid leukodystrophy
- gllboid leukodystrophy
- glpboid leukodystrophy
- gl0boid leukodystrophy
- gl9boid leukodystrophy
- glovoid leukodystrophy
- glonoid leukodystrophy
- glohoid leukodystrophy
- glogoid leukodystrophy
- globiid leukodystrophy
Etymology of GLOBOID LEUKODYSTROPHY
The word "Globoid Leukodystrophy" is a medical term used to describe a rare genetic disorder. Its etymology can be broken down as follows:
1. Globoid: The term "globoid" comes from the Greek word "globos", which means "a ball" or "a sphere". In medical terminology, "globoid" refers to a shape resembling a sphere.
2. Leukodystrophy: "Leukodystrophy" is derived from two components: "leuko" and "dystrophy".
- Leuko: This prefix is derived from the Greek word "leukos", meaning "white". In medicine, "leuko" is associated with conditions related to white or pale tissues/organs.
- Dystrophy: This word is of Greek origin, derived from "dystrophia", which means "malnourishment".
