FC GAMMA RIII Meaning and
Definition
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Fc gamma RIII, also known as FcγRIII, is a receptor protein found on the surface of various immune cells, including natural killer (NK) cells and macrophages. It belongs to the Fc gamma receptor family and specifically binds to the Fc region of immunoglobulin G (IgG) antibodies.
The Fc gamma RIII receptor plays a vital role in mediating the effector functions of the immune system, particularly in antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Upon binding to the Fc region of IgG antibodies, FcγRIII triggers a series of downstream signaling events that activate the immune cells.
Fc gamma RIII exists in multiple forms with distinct affinities and cellular distributions, including FcγRIIIA and FcγRIIIB. FcγRIIIA is primarily expressed on NK cells and monocytes, while FcγRIIIB is mainly found on neutrophils. These different forms of receptors differ in their binding affinities for IgG antibodies and can initiate different immune responses based on their specific cellular expression patterns.
The engagement of FcγRIII with immunoglobulin complexes not only helps in the elimination of pathogens but also plays a crucial role in the therapeutic efficacy of monoclonal antibody-based immunotherapies. Understanding the functions and interactions of Fc gamma RIII is significant in immunology research and developing targeted therapies for various diseases, including cancer, autoimmune disorders, and infectious diseases.
Common Misspellings for FC GAMMA RIII
- dc gamma riii
- cc gamma riii
- vc gamma riii
- gc gamma riii
- tc gamma riii
- rc gamma riii
- fx gamma riii
- fv gamma riii
- ff gamma riii
- fd gamma riii
- fc famma riii
- fc vamma riii
- fc bamma riii
- fc hamma riii
- fc yamma riii
- fc tamma riii
- fc gzmma riii
- fc gsmma riii
- fc gwmma riii
- fc gqmma riii
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