Fc gamma RI, also known as CD64, is a receptor protein found on the surface of certain immune cells, such as macrophages, monocytes, and dendritic cells. It plays a crucial role in the immune response by binding to the Fc region of immunoglobulin G (IgG) antibodies.
The Fc gamma RI receptor is a member of the Fc gamma receptor family, which consists of several different types of receptors that mediate the interactions between antibodies and immune cells. Fc gamma RI is the high-affinity receptor in this family, meaning that it has the highest binding affinity for IgG antibodies compared to other Fc gamma receptors.
When an immune cell expressing Fc gamma RI comes into contact with an IgG antibody that has bound to its corresponding antigen, the Fc region of the antibody binds to the Fc gamma RI receptor on the immune cell. This binding triggers a series of signaling events within the immune cell, leading to the activation and subsequent elimination of the pathogen or foreign substance.
Fc gamma RI is involved in multiple immune functions, including phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and immune complex clearance. It plays a crucial role in host defense against infections and the clearance of immune complexes from the body.
Overall, Fc gamma RI is an important receptor protein that facilitates the recognition and elimination of pathogens and foreign substances by linking antibodies to immune cells.
