ERBA GENES Meaning and
Definition
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The erbA genes refer to a family of genes that encode for nuclear receptors involved in regulating gene expression. These genes are part of the thyroid hormone receptor family, also known as NR1A subfamily, and are named after the avian erythroblastosis virus (erbA). The erbA genes play a crucial role in the proper functioning of the endocrine system, particularly in thyroid hormone signaling pathways.
There are two main erbA genes, erbA-alpha and erbA-beta, which produce distinct protein isoforms. The erbA-alpha gene is located on human chromosome 17, while the erbA-beta gene is found on chromosome 3. These genes are highly conserved across different species, indicating their significance in biological processes.
The protein products of erbA genes act as ligand-activated transcription factors, meaning that they regulate the transcription of specific genes by binding to specific DNA sequences called hormone response elements. Thyroid hormones, such as triiodothyronine (T3) and thyroxine (T4), bind to the erbA receptors and activate or repress the expression of target genes, thereby exerting control over various physiological processes, including metabolism, development, and growth.
Dysregulation or mutations in erbA genes can have significant consequences on overall health. Inappropriate activation or loss of function of erbA receptors may lead to metabolic disorders, developmental abnormalities, and dysfunctions in energy balance. Understanding the role and mechanisms of erbA genes has proven essential for exploring the complexities of hormonal regulation and the pathogenesis of related diseases.
Common Misspellings for ERBA GENES
- wrba genes
- srba genes
- drba genes
- rrba genes
- 4rba genes
- 3rba genes
- eeba genes
- edba genes
- efba genes
- etba genes
- e5ba genes
- e4ba genes
- erva genes
- erna genes
- erha genes
- erga genes
- erbz genes
- erbs genes
- erbw genes
- erbq genes
Etymology of ERBA GENES
The word "erbA Genes" is derived from the combination of "erbA" and "genes".
The term "erbA" stands for "erbB-related protein A". It originates from the name of the erbA oncogene, which was initially identified in avian erythroblastosis virus and later found to be related to the human proto-oncogene c-erbB. "ErbA" is an acronym for erythroblast transformation-specific Amino-terminal domain.
The word "genes" refers to the segments of DNA that contain instructions for producing specific proteins. It has its roots in the Latin word "genus", meaning "birth" or "origin".
When used together, "erbA genes" refers to the family of genes that code for the erbA proteins, which are transcription factors involved in regulating gene expression. These genes play essential roles in various cellular processes, including development and metabolism.
