Encephalitis Lethargica is a neurological disorder that emerged in the early 20th century. The spelling of this word can be challenging for those not familiar with medical terminology. The word "Encephalitis" is spelled /ˌɛnsefəˈlaɪtɪs/ with the stress on the second syllable. The word "Lethargica" is pronounced /lɛˈθɑrʤɪkə/ with the stress on the third syllable. Encephalitis Lethargica manifests as a prolonged sleep-like state and can cause permanent neurological damage. Its cause is still unknown, and treatments are palliative.
Encephalitis Lethargica is a rare neurological disorder characterized by inflammation of the brain, specifically the basal ganglia and midbrain. The condition was first identified in the early 20th century during the global pandemic of Influenza, but the exact cause remains unknown. The condition primarily affects the central nervous system, leading to a range of symptoms including high fever, headache, fatigue, muscle weakness, and various neurological abnormalities.
Encephalitis Lethargica is often referred to as "sleepy sickness" due to its characteristic symptom of excessive sleepiness or prolonged periods of altered consciousness. However, the condition may also cause symptoms such as movement disorders, including Parkinsonism, as well as psychiatric symptoms like depression, irritability, and psychosis. In severe cases, the disorder can lead to a state of catatonia, where the patient may become immobile and unresponsive.
The natural course of Encephalitis Lethargica can be unpredictable, with symptoms worsening, improving, or even disappearing temporarily. Some individuals may experience long-term complications, while others may recover spontaneously. Treatment generally focuses on managing symptoms and providing supportive care. Various medications, including antiviral drugs and immunomodulatory therapies, are sometimes prescribed, but their effectiveness remains limited.
Although Encephalitis Lethargica is a rare disorder, its historical significance lies in the fact that it provided insights into the study of neurology and the understanding of infectious diseases affecting the brain. Further research is warranted to unravel the complex etiology and pathophysiology of this enigmatic condition.
Nona, a form occurring epidemically, often apparently in association with influenza, marked by apathy, somnolence, diplopia, and extreme muscular weakness.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "Encephalitis Lethargica" comes from Greek and Latin roots.
"Encephalitis" is derived from the Greek words "enkephalos" meaning "within the head" and "itis" meaning "inflammation". Therefore, encephalitis refers to the inflammation of the brain.
"Lethargica" is derived from the Greek word "lethargikos" which means "pertaining to lethargy". Lethargy refers to a state of extreme drowsiness or fatigue.
When combined, "Encephalitis Lethargica" literally means "inflammation of the brain causing lethargy". This term was coined by the Austrian neurologist Constantin von Economo, who first described this condition in the early 20th century.