DOLICHOL MONOPHOSPHATE MANNOSE Meaning and
Definition
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Dolichol Monophosphate Mannose (Dol-P-Man) is a compound that plays a crucial role in the process of protein glycosylation in cells. It is a type of sugar molecule called a monosaccharide, specifically a mannose derivative, which is attached to a lipid-like molecule called dolichol phosphate.
Glycosylation is a post-translational modification that involves the attachment of sugar molecules to proteins, forming glycoproteins. This process is essential for the proper folding, stability, and function of many proteins in the body. Dol-P-Man serves as the carrier molecule for transporting mannose to the growing protein chain during glycosylation.
In the initial steps of protein glycosylation, Dol-P-Man is synthesized within the endoplasmic reticulum (ER) membrane of cells. Mannose is added to dolichol phosphate through a series of enzymatic reactions, resulting in the formation of Dol-P-Man. This complex molecule is then recognized by specific enzymes, which transfer the mannose moiety onto target proteins.
Defects in the synthesis or utilization of Dol-P-Man can lead to various genetic disorders known as congenital disorders of glycosylation (CDGs). CDGs are characterized by impaired protein glycosylation, resulting in a wide range of clinical symptoms affecting multiple organ systems.
In summary, Dolichol Monophosphate Mannose is a sugar-derived compound that acts as a carrier molecule for mannose during protein glycosylation. Its role is crucial for the proper functioning of glycoproteins and any disruption in its synthesis or utilization can lead to severe genetic disorders.
Common Misspellings for DOLICHOL MONOPHOSPHATE MANNOSE
- solichol monophosphate mannose
- xolichol monophosphate mannose
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- folichol monophosphate mannose
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- doluchol monophosphate mannose
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- dolochol monophosphate mannose
- dol9chol monophosphate mannose
