DNA PRIMASE Meaning and
Definition
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DNA primase is an enzyme responsible for synthesizing short RNA primers during DNA replication. Primase is an essential component of the DNA primosome, a protein complex involved in initiating the DNA replication process. It catalyzes the synthesis of RNA primers that initiate DNA synthesis by providing a starting point for DNA polymerase to attach and begin replicating the DNA molecule.
As a specialized RNA polymerase, DNA primase recognizes specific DNA sequences called origins of replication, typically located at the replication fork. Once bound to the DNA template, primase synthesizes a short RNA chain, known as a primer, complementary to the DNA template strand. This primer provides the necessary 3'-OH group for DNA polymerase to add nucleotides and extend the growing DNA chain.
DNA primase exhibits high specificity for its DNA template and initiates synthesis using ribonucleotides, the building blocks of RNA. However, the RNA primers synthesized by primase are rapidly removed and replaced with DNA nucleotides during replication, ensuring the accuracy and stability of the newly synthesized DNA strands.
Overall, DNA primase plays a crucial role in DNA replication by generating RNA primers that serve as starting points for DNA synthesis. Its precise and timely activity is essential for the faithful replication of genetic material and the maintenance of genome integrity.
Common Misspellings for DNA PRIMASE
- sna primase
- xna primase
- cna primase
- fna primase
- rna primase
- ena primase
- dba primase
- dma primase
- dja primase
- dha primase
- dnz primase
- dns primase
- dnw primase
- dnq primase
- dna orimase
- dna lrimase
- dna -rimase
- dna 0rimase
- dna peimase
- dna pdimase
Etymology of DNA PRIMASE
The term "DNA primase" is derived from its two components: "DNA" and "primase".
1. DNA: DNA stands for Deoxyribonucleic Acid, which is a molecule that contains the genetic instructions for the development and functioning of all living organisms. The term DNA was coined by the Swiss biochemist Friedrich Miescher, who first isolated the substance from cells in 1869. The abbreviation "DNA" gained widespread use in the mid-20th century after researchers discovered its role in heredity and genetics.
2. Primase: Primase is an enzyme responsible for synthesizing short RNA primers during DNA replication. The term "primase" is derived from the Latin word "primus", meaning "first" or "beginning".
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