How Do You Spell DIPEPTIDYL PEPTIDASE IV?

Pronunciation: [dˈa͡ɪpptɪdˌɪl pˈɛptɪdˌe͡ɪs ɹˌə͡ʊmən fˈɔː] (IPA)

The word "Dipeptidyl Peptidase IV" is a mouthful to say, let alone spell. Its proper pronunciation is /daɪˌpɛptɪdəl ˈpɛptɪdeɪs aɪ ˌvi/. The word is made up of several individual components, starting with "di-" meaning "two," then "peptidyl" indicating a peptide bond, and "peptidase" meaning an enzyme that breaks down peptide bonds. Finally, the Roman numeral "IV" denotes that it is the fourth isoform of the enzyme. Altogether, its spelling accurately represents its complex molecular structure.

DIPEPTIDYL PEPTIDASE IV Meaning and Definition

1. Dipeptidyl peptidase IV (DPP-IV) is an enzyme that plays a crucial role in the regulation of glucose metabolism, particularly in the context of diabetes. It is a transmembrane protein found on the surface of various cell types, including endothelial cells in the digestive tract and immune cells.

   The primary function of DPP-IV is the cleavage of certain peptide bonds involving the amino acid proline in the N-terminal position of peptides. It catalyzes the removal of dipeptides (two amino acids) from the peptide chain, hence the name dipeptidyl peptidase. DPP-IV is specifically responsible for the inactivation of incretin hormones, which are involved in the control of blood sugar levels. Incretins are released by the intestines in response to food intake and enhance insulin secretion from pancreatic beta cells, leading to lowered blood glucose levels.

   The inhibition of DPP-IV activity has been a therapeutic target for the management of type 2 diabetes, as it increases the levels of active incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This inhibition prolongs the effects of these hormones by preventing their rapid degradation, leading to increased insulin release and reduced glucagon secretion by the pancreas. DPP-IV inhibitors, such as sitagliptin and linagliptin, are commonly used as antidiabetic medications to control blood sugar levels in individuals with type 2 diabetes.

   Overall, DPP-IV is a crucial enzyme involved in glucose homeostasis, and its inhibition represents an important therapeutic approach for the management of diabetes.

Common Misspellings for DIPEPTIDYL PEPTIDASE IV

• sipeptidyl peptidase iv
• xipeptidyl peptidase iv
• cipeptidyl peptidase iv
• fipeptidyl peptidase iv
• ripeptidyl peptidase iv
• eipeptidyl peptidase iv
• dupeptidyl peptidase iv
• djpeptidyl peptidase iv
• dkpeptidyl peptidase iv
• dopeptidyl peptidase iv
• d9peptidyl peptidase iv
• d8peptidyl peptidase iv
• dioeptidyl peptidase iv
• dileptidyl peptidase iv
• di-eptidyl peptidase iv
• di0eptidyl peptidase iv
• dipwptidyl peptidase iv
• dipsptidyl peptidase iv
• dipdptidyl peptidase iv
• diprptidyl peptidase iv

Similar spelling words for DIPEPTIDYL PEPTIDASE IV

• dipeptidyl peptidase-4 inhibitor,
• dipeptidyl peptidase-4 inhibitors,
• Dipeptidyl Peptidase I,
• Dipeptidyl Peptidase A.