How Do You Spell DIPEPTIDYL AMINOPEPTIDASE I?

Pronunciation: [dˈa͡ɪpptɪdˌɪl ɐmˈɪnə͡ʊpptˌɪde͡ɪs ˈa͡ɪ] (IPA)

Dipeptidyl Aminopeptidase I is a complex medical term that can be challenging to spell. Using the International Phonetic Alphabet (IPA), it can be broken down into individual sounds and syllables. The first syllable is "di-" which is pronounced as "daɪ". The next part is "peptidyl" which is pronounced as "pɛptɪdɪl". The next syllable is "amino" which is pronounced as "æmɪnoʊ". The last part is "peptidase I" which is pronounced as "pɛptɪdeɪs I". By breaking it down phonetically, you can confidently spell out this complex term.

DIPEPTIDYL AMINOPEPTIDASE I Meaning and Definition

1. Dipeptidyl Aminopeptidase I (DAP I) is an enzyme that belongs to the peptidase family and is primarily found in lysosomes, which are cellular compartments responsible for degradation and recycling of macromolecules. It plays a crucial role in the final step of proteolytic processing of lysosomal enzyme precursors, particularly cysteine cathepsins.

   The catalytic activity of DAP I involves the removal of dipeptides from the amino terminus of protein substrates, specifically by cleaving the bond between the two terminal amino acids. It is an exopeptidase, meaning it acts on the ends of peptide chains rather than in the middle. DAP I plays a significant role in the maturation and activation of several lysosomal enzymes and is vital for maintaining proper lysosomal function.

   Deficiencies or mutations in DAP I can lead to lysosomal storage disorders and impair the normal processing of lysosomal enzyme precursors, resulting in their accumulation and dysfunction. This can have severe consequences on cellular homeostasis and contribute to the development of various diseases.

   DAP I is also referred to as Cathepsin C or dipeptidyl peptidase I (DPPI). It is widely distributed in various tissues throughout the body, although it is most abundant in leukocytes, particularly granulocytes and macrophages. DAP I is considered an important therapeutic target for the treatment of lysosomal storage disorders and potentially other diseases associated with abnormal lysosomal functioning.

Common Misspellings for DIPEPTIDYL AMINOPEPTIDASE I

• sipeptidyl aminopeptidase i
• xipeptidyl aminopeptidase i
• cipeptidyl aminopeptidase i
• fipeptidyl aminopeptidase i
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• dileptidyl aminopeptidase i
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• di0eptidyl aminopeptidase i
• dipwptidyl aminopeptidase i
• dipsptidyl aminopeptidase i
• dipdptidyl aminopeptidase i
• diprptidyl aminopeptidase i