How Do You Spell DIHYDROPTERIDINE REDUCTASE?

Pronunciation: [da͡ɪhˈa͡ɪdɹəptəɹˌɪdiːn ɹɪdˈʌkte͡ɪs] (IPA)

The word "Dihydropteridine Reductase" is a mouthful to pronounce, but understanding its scientific significance is quite intriguing. This term is commonly used in the field of biochemistry and genetics where it refers to an enzyme that plays a significant role in the synthesis of neurotransmitters such as serotonin and dopamine. The IPA transcription of "Dihydropteridine Reductase" is /ˌdaɪˌhaɪdroʊˈpɜrtədiːn rɪˈdʌktɪs/ which accurately represents the pronunciation of the various syllables and phonemes in the word.

DIHYDROPTERIDINE REDUCTASE Meaning and Definition

1. Dihydropteridine reductase, also known as DHPR, is an enzyme involved in the synthesis and recycling of tetrahydrobiopterin (BH4), an important co-factor in various enzymatic reactions within the body. It plays a critical role in maintaining the balance of BH4 levels, which is crucial for the proper functioning of several biological processes.

   DHPR is responsible for catalyzing the conversion of dihydrobiopterin (BH2) to BH4 through the reduction of a pteridine ring. This reaction is a vital step in the regeneration of BH4, as it allows for the recycling of BH2, which is formed as a byproduct in several enzymatic reactions.

   The enzyme DHPR is primarily found in the liver, intestines, and other tissues of the body, including, to a lesser extent, in the brain. It is encoded by the QDPR gene and is comprised of 117 amino acids, forming a compact structure necessary for its enzymatic activity.

   Deficiencies or mutations in the DHPR enzyme can lead to a condition called dihydropteridine reductase deficiency, which is a rare inherited disorder characterized by the impaired recycling of BH2 to BH4. This deficiency disrupts the synthesis of certain neurotransmitters and can result in neurological symptoms such as developmental delay, movement disorders, and intellectual disability.

   In summary, dihydropteridine reductase is an enzyme that plays a crucial role in the synthesis and recycling of BH4, a co-factor essential for various enzymatic reactions in the body. Deficiencies or mutations in this enzyme can lead to a rare genetic disorder known as dihydropteridine reductase deficiency, which can cause various neurological symptoms.

Common Misspellings for DIHYDROPTERIDINE REDUCTASE

• sihydropteridine reductase
• xihydropteridine reductase
• cihydropteridine reductase
• fihydropteridine reductase
• rihydropteridine reductase
• eihydropteridine reductase
• duhydropteridine reductase
• djhydropteridine reductase
• dkhydropteridine reductase
• dohydropteridine reductase
• d9hydropteridine reductase
• d8hydropteridine reductase
• digydropteridine reductase
• dibydropteridine reductase
• dinydropteridine reductase
• dijydropteridine reductase
• diuydropteridine reductase
• diyydropteridine reductase
• dihtdropteridine reductase
• dihgdropteridine reductase

Etymology of DIHYDROPTERIDINE REDUCTASE

The word "dihydropteridine reductase" has its etymology rooted in the Greek language.

1. Dihydropteridine: The term "dihydropteridine" is composed of two components - "dihydro" and "pteridine".

- "Dihydro" comes from the Greek word "di-" meaning two or double and "hydro" meaning water or hydrogen. It indicates that there are two hydrogens present in the molecule of interest.

- "Pteridine", on the other hand, is derived from the Greek word "ptéryx" meaning wing. It refers to a group of heterocyclic compounds that contain a fused pyrimidine ring system, resembling the shape of a wing.

2. Reductase: The term "reductase" is derived from the Latin verb "reducere", meaning to bring back or restore.