How Do You Spell DIHYDROOROTATE OXIDASE?

Pronunciation: [da͡ɪhˈa͡ɪdɹɔːɹˌə͡ʊte͡ɪt ˈɒksɪdˌe͡ɪs] (IPA)

The spelling of "Dihydroorotate Oxidase" may seem overwhelming, but it can be explained using the International Phonetic Alphabet (IPA). The pronunciation of this term is [daɪˈhaɪdrəʊˈɔːrəteɪt ˈɒksɪdeɪs]. The long "i" sound in "dihydro" is represented by the IPA symbol [aɪ], and the "or" sound in "orotate" is represented by [ɔː]. The emphasis is placed on the second syllable of "dihydroorotate" and the first syllable of "oxidase." By breaking down the pronunciation using IPA symbols, it becomes easier to spell and correctly pronounce this scientific term.

DIHYDROOROTATE OXIDASE Meaning and Definition

1. Dihydroorotate oxidase, also known as DHODH, is an enzyme that plays a crucial role in the synthesis of pyrimidine nucleotides, which are essential building blocks of DNA and RNA. Specifically, it catalyzes the oxidation of dihydroorotate, a compound derived from the de novo synthesis of pyrimidines, to orotate. This chemical reaction is a key step in the conversion of orotic acid, a precursor molecule, into uridine monophosphate (UMP), a pyrimidine nucleotide.

   DHODH is found in all living organisms, from bacteria to humans, and it utilizes a flavin mononucleotide (FMN) cofactor to carry out the oxidation reaction. The enzyme is primarily located in the inner mitochondrial membrane, where it participates in the electron transport chain, specifically in the ubiquinone (CoQ) pool, transferring electrons from dihydroorotate to CoQ.

   Inhibition of DHODH has been explored as a potential therapeutic strategy against various diseases, particularly cancer and autoimmune disorders, due to its crucial role in the proliferation and function of rapidly dividing cells. Several drugs have been developed to target DHODH, including leflunomide, an immunosuppressive agent, and brequinar, an experimental anticancer drug.

   Overall, dihydroorotate oxidase is an essential enzyme involved in the synthesis of pyrimidine nucleotides, and its inhibition represents a promising avenue for the development of therapeutics targeting cellular proliferation and immune responses.

Common Misspellings for DIHYDROOROTATE OXIDASE

• sihydroorotate oxidase
• xihydroorotate oxidase
• cihydroorotate oxidase
• fihydroorotate oxidase
• rihydroorotate oxidase
• eihydroorotate oxidase
• duhydroorotate oxidase
• djhydroorotate oxidase
• dkhydroorotate oxidase
• dohydroorotate oxidase
• d9hydroorotate oxidase
• d8hydroorotate oxidase
• digydroorotate oxidase
• dibydroorotate oxidase
• dinydroorotate oxidase
• dijydroorotate oxidase
• diuydroorotate oxidase
• diyydroorotate oxidase
• dihtdroorotate oxidase
• dihgdroorotate oxidase

Etymology of DIHYDROOROTATE OXIDASE

The word "dihydroorotate oxidase" has a scientific and technical origin related to the field of biochemistry.

The word "dihydroorotate" is a compound term consisting of two parts: "dihydro" and "orotate".

- "Dihydro" is derived from the Greek word "di", meaning "two", and "hydro", referring to "hydrogen". In biochemistry, "dihydro" is used to indicate the presence of two hydrogen atoms in a compound.

- "Orotate" comes from the chemical compound called "orotic acid". It is a heterocyclic compound composed of carbon, hydrogen, oxygen, and nitrogen atoms, often found in nucleic acids.

The term "oxidase" refers to a type of enzyme that catalyzes oxidation reactions, involving the transfer of electrons from a substrate molecule to an electron acceptor, usually oxygen.