Diffuse Large Follicular Center Cell Lymphoma (DLFCCL) is a type of non-Hodgkin lymphoma, which is a cancer that develops in the lymphatic system. DLFCCL specifically originates in the lymph nodes and affects the B-cells, which are a type of white blood cell involved in the immune system's response to infections.
DLFCCL is characterized by the growth of abnormal B-cells in the lymph nodes, which leads to the formation of enlarged lymph nodes. These abnormal cells have a large nucleus and are called centroblasts. They often replace the normal follicular center cells that are responsible for producing antibodies and maintaining immune function.
The term "diffuse" refers to the spread of cancer cells throughout the lymph nodes rather than a localized collection of cells. This type of lymphoma is commonly described as "large cell" due to the significant size of the malignant centroblasts.
DLFCCL can present with various symptoms, including swollen lymph nodes, fever, weight loss, fatigue, and night sweats. Diagnosis is typically made through a combination of physical examination, imaging tests, blood tests, and biopsy of an affected lymph node.
Treatment for DLFCCL usually involves chemotherapy, which uses drugs to kill cancer cells, and in some cases, radiation therapy or immunotherapy. The specific treatment approach depends on factors such as the stage of the disease and the individual's overall health.
Overall, DLFCCL is a fast-growing and aggressive form of lymphoma that requires prompt medical intervention for effective management.
