How Do You Spell DELTA AMINOLEVULINIC ACID SYNTHETASE?

Pronunciation: [dˈɛltəɹ ɐmˌɪnə͡ʊlvjʊlˈɪnɪk ˈasɪd sˈɪnθɪtˌe͡ɪs] (IPA)

Delta Aminolevulinic Acid Synthetase is a mouthful of a word, and it can be quite challenging to spell correctly for many people. The word is pronounced as /ˈdɛltə əˌmiːnoʊˌlɛvjʊˌlɪnɪk ˈæsɪd ˈsɪnθəteɪz/ in IPA phonetic transcription. The spelling of the word can be quite complicated due to its long and complex nature. It is essential to break down the spelling into shorter syllables and understand the sound of each letter to spell it correctly. A systematic approach can help in mastering the spelling of this word.

DELTA AMINOLEVULINIC ACID SYNTHETASE Meaning and Definition

1. Delta aminolevulinic acid synthetase (ALAS) is an enzyme that plays a crucial role in the production of heme, a vital component of hemoglobin and certain enzymes in the body. Located in the mitochondria of cells, this enzyme is responsible for catalyzing the first and rate-limiting step in the biosynthesis of heme.

   ALAS facilitates the conversion of glycine and succinyl-CoA, two precursors, into delta-aminolevulinic acid (ALA). This process, known as the ALA synthesis pathway, is tightly regulated to ensure the appropriate and controlled production of heme. The enzymatic activity of ALAS is influenced by various factors, including the availability of substrates, feedback regulation, and hormonal and growth factor signals.

   Deficiencies or mutations in delta aminolevulinic acid synthetase can lead to a range of disorders and diseases, such as porphyrias, which are a group of rare metabolic disorders characterized by the impaired production of heme. Porphyrias can manifest as acute attacks or chronic symptoms, depending on the specific enzyme deficiency. Additionally, mutations in the gene encoding ALAS can result in hereditary sideroblastic anemia, a condition characterized by impaired hemoglobin synthesis.

   Understanding the function and regulation of delta aminolevulinic acid synthetase is important for elucidating the underlying mechanisms of heme synthesis and related disorders. The enzyme is a focal point in the control of heme production and serves as a potential target for therapeutic interventions aimed at correcting deficiencies or dysregulations in heme metabolism.

Common Misspellings for DELTA AMINOLEVULINIC ACID SYNTHETASE

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