How Do You Spell DELTA AMINOLEVULINATE DEHYDRATASE?

Pronunciation: [dˈɛltəɹ ɐmˌɪnə͡ʊlvjˈʊlɪnˌe͡ɪt dˌiːha͡ɪdɹˈate͡ɪs] (IPA)

Delta aminolevulinate dehydratase is a difficult word to spell due to its long length and complex pronunciation. The IPA phonetic transcription for this word would be /ˈdɛltə əˌminoʊˌlɛvjuːlɪˌneɪt diːˈhaɪdreɪteɪs/ which reflects the various vowels and consonants present in this scientific term. This enzyme plays a crucial role in the heme biosynthesis pathway in the body, and although the spelling may seem daunting, it is important for medical professionals and researchers to be familiar with it in order to accurately discuss and understand relevant topics.

DELTA AMINOLEVULINATE DEHYDRATASE Meaning and Definition

1. Delta aminolevulinate dehydratase (ALAD) is an enzyme that plays a crucial role in the heme biosynthesis pathway. It is responsible for catalyzing the second step in the pathway, converting delta-aminolevulinic acid (ALA) into porphobilinogen. ALAD is also known as porphobilinogen synthase or ALAS2.

   ALAD is a pyridoxal 5'-phosphate (PLP)-dependent enzyme found in the cytoplasm of many tissues, particularly in the liver and red blood cells. The enzyme utilizes PLP as a cofactor, which is required for its catalytic activity. ALAD carries out a condensation reaction, forming a pyrrole ring by removing water molecule from two molecules of ALA. This reaction is an essential step in the pathway leading to the synthesis of heme, an integral component of hemoglobin and other important enzymes.

   Deficiencies in ALAD activity have been associated with a rare genetic disorder known as ALAD deficiency porphyria, characterized by a buildup of ALA and its precursor porphobilinogen, leading to the accumulation of toxic intermediates. Symptoms of this disorder include abdominal pain, neuropathy, and psychiatric disturbances. Additionally, the activity of ALAD can be inhibited by various environmental factors such as heavy metals including lead, leading to impaired heme production and subsequent negative effects on the body.

   In summary, delta aminolevulinate dehydratase is an enzyme that functions in the biosynthesis of heme, catalyzing the conversion of ALA into porphobilinogen. It is essential for the production of heme, important for the proper functioning of hemoglobin and other enzymes.

Common Misspellings for DELTA AMINOLEVULINATE DEHYDRATASE

• selta aminolevulinate dehydratase
• xelta aminolevulinate dehydratase
• celta aminolevulinate dehydratase
• felta aminolevulinate dehydratase
• relta aminolevulinate dehydratase
• eelta aminolevulinate dehydratase
• dwlta aminolevulinate dehydratase
• dslta aminolevulinate dehydratase
• ddlta aminolevulinate dehydratase
• drlta aminolevulinate dehydratase
• d4lta aminolevulinate dehydratase
• d3lta aminolevulinate dehydratase
• dekta aminolevulinate dehydratase
• depta aminolevulinate dehydratase
• deota aminolevulinate dehydratase
• delra aminolevulinate dehydratase
• delfa aminolevulinate dehydratase
• delga aminolevulinate dehydratase
• delya aminolevulinate dehydratase
• del6a aminolevulinate dehydratase