DEIODINASE Meaning and
Definition
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Deiodinase refers to an enzyme that plays a crucial role in the regulation of thyroid hormone metabolism within the body. Thyroid hormones, specifically triiodothyronine (T3) and thyroxine (T4), produced by the thyroid gland, are responsible for controlling numerous physiological functions such as growth, development, metabolism, and energy production. However, T4 is relatively inactive and needs to be converted into the active form, T3, to exert its effects on target cells and tissues.
This is where deiodinase comes into play. Deiodinase enzymes are responsible for catalyzing the removal of iodine atoms from the T4 molecule, leading to the conversion of T4 to T3. This process, known as deiodination, occurs mainly in various tissues throughout the body, such as the liver, kidneys, and skeletal muscles.
There are three types of deiodinase enzymes: type 1 (D1), type 2 (D2), and type 3 (D3). Each type is localized in different tissues and has distinct functions. D1 and D2 are responsible for the activation of T4 to T3, while D3 acts as an inactivator by converting T4 and T3 to inactive forms, such as reverse T3 (rT3) or 3,3'-diiodothyronine (3,3'-T2).
The activity of deiodinase enzymes is finely regulated in response to various factors, including feedback signals from the hypothalamus and pituitary gland, as well as changes in thyroid hormone levels. Dysregulation or dysfunction of deiodinase enzymes can lead to imbalances in thyroid hormone levels, resulting in disorders such as hypothyroidism or hyperthyroid
Common Misspellings for DEIODINASE
Etymology of DEIODINASE
The word "deiodinase" is derived from two components: "de-", which is a prefix meaning "removal" or "reversal", and "iodinase", which itself is derived from the word "iodine".
The term "iodine" originates from the Greek word "iodes", which means "violet-colored". It was given this name due to the purple hue of iodine vapor. Iodine is a chemical element with the symbol I and is commonly used in medical and industrial applications.
The suffix "-ase" typically denotes an enzyme, which is a protein that catalyzes specific chemical reactions in living organisms. Therefore, "deiodinase" refers to an enzyme that is responsible for the removal or reversal of iodine.
In the context of biology, "deiodinases" are a group of enzymes involved in the conversion of thyroid hormones.
Similar spelling words for DEIODINASE
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- TITNS,
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- daytonas,
- deutons,
- Tutnose,
- deadens.
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