DEAMIDIZING ENZYME Meaning and
Definition
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A deamidizing enzyme is a specific type of enzyme that catalyzes the process of deamidization, which involves the removal of the amide group (-CONH₂) from a molecule. Deamidization is a crucial reaction in various biological processes, as it modifies the chemical structure of molecules to regulate their functionality and activity.
These specialized enzymes exert their catalytic activity by specifically recognizing molecules containing an amide group and facilitating the enzymatic cleavage of the amide bond. This process involves the addition of a water molecule, leading to the hydrolysis of the amide linkage. As a result, the amide group is transformed into a carboxyl group (-COOH) and an amino group (-NH₂), ultimately resulting in the deamidized product.
Deamidizing enzymes play a vital role in a range of biological functions, including protein turnover, signaling pathways, and immune system responses. These enzymes are also involved in the modification of various proteins and peptides, affecting their structure, function, and stability.
Researchers have identified several specific deamidizing enzymes within different organisms, such as the peptidylarginine deaminase (PAD) enzymes found in mammals or tRNA deamidases found in bacteria. These enzymes often exhibit high specificity toward particular substrates, enabling them to selectively target specific molecules for deamidization.
Understanding the function and mechanism of deamidizing enzymes is essential for advancing our knowledge of various biological processes and has significant implications for areas such as drug development, biotechnology, and disease treatments.
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One which decomposes the amino-acids into ammonia compounds.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for DEAMIDIZING ENZYME
- seamidizing enzyme
- xeamidizing enzyme
- ceamidizing enzyme
- feamidizing enzyme
- reamidizing enzyme
- eeamidizing enzyme
- dwamidizing enzyme
- dsamidizing enzyme
- ddamidizing enzyme
- dramidizing enzyme
- d4amidizing enzyme
- d3amidizing enzyme
- dezmidizing enzyme
- desmidizing enzyme
- dewmidizing enzyme
- deqmidizing enzyme
- deanidizing enzyme
- deakidizing enzyme
- deajidizing enzyme
- deamudizing enzyme
Etymology of DEAMIDIZING ENZYME
The word "deamidizing" is derived from the verb "deamidize" which involves the process of removing an amide group from a molecule.
The term "deamidize" originates from the combination of two Latin roots:
1. "De-" is a prefix in Latin meaning "to reverse" or "to remove". It indicates a negation or undoing of the following root or action.
2. "Amide" refers to a functional group in chemistry comprising a carbonyl group (CO) bonded to a nitrogen atom (N). The term "amide" is derived from the Latin word "amideum", which means "a compound of nitrogen and hydrogen".
Hence, combining "de-" and "amide" gives "deamidize", which describes the action of reversing or removing the amide group.
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