DEAMIDIZE Meaning and
Definition
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Deamidize is a verb that refers to the process of removing or converting the amide group from a compound, typically a protein or a peptide. The amide group is a functional group consisting of an amino group (NH2) and a carbonyl group (C=O) bonded to a nitrogen atom. Deamidation is an important post-translational modification that can occur in proteins under certain conditions, affecting their structure and function.
In the context of biochemistry and molecular biology, deamidation commonly occurs spontaneously and is a reversible reaction. It involves the hydrolysis of the peptide bond between the nitrogen and carbonyl groups of two adjacent amino acids, resulting in the release of ammonia (NH3). This process can have significant consequences on the protein's stability, folding, enzymatic activity, antigenicity, and binding properties, among others.
Deamidize may also be used to describe a deliberate chemical or enzymatic procedure to specifically remove or modify the amide group from a compound. This process often requires the use of specific reagents or enzymes that can selectively target the amide bonds and modify them accordingly.
Overall, deamidize is a term used to describe the action of removing or modifying the amide group in proteins and peptides, either spontaneously or deliberately. It plays a crucial role in various biological processes and can have profound effects on the functional properties of biomolecules.
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To decompose amino-acids into ammonia compounds.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for DEAMIDIZE
- seamidize
- xeamidize
- ceamidize
- feamidize
- reamidize
- eeamidize
- dwamidize
- dsamidize
- ddamidize
- dramidize
- d4amidize
- d3amidize
- dezmidize
- desmidize
- dewmidize
- deqmidize
- deanidize
- deakidize
- deajidize
- deamudize
Etymology of DEAMIDIZE
The word "deamidize" is derived from the combination of two separate word components: "de-" and "amidize".
1. The prefix "de-" is derived from the Latin word "de", which means "down", "away", or "remove". It is commonly used to indicate the reversal, removal, or negation of a certain action or state.
2. The term "amidize" is derived from the word "amide", which refers to a class of organic compounds that contain the amide functional group (-CONH2). The suffix "-ize" is used to indicate the process of making or converting something into a specific state or condition.
Combining these two components, "deamidize" essentially means the process of removing or reversing the amide functional group from a compound.
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