D TUBOCURARINE Meaning and
Definition
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d Tubocurarine, also known as Tubocurarine, is a naturally occurring alkaloid compound extracted from the bark of certain South American plants, including Chondrodendron tomentosum and other species of the Strychnos family. It is renowned for its potent neuromuscular blocking properties and has been widely used in medicine as a muscle relaxant and anesthesia adjunct.
As a competitive nicotinic acetylcholine receptor antagonist, d Tubocurarine competitively inhibits the binding of acetylcholine to the postsynaptic receptor sites at the neuromuscular junction, thereby preventing the depolarization of muscle cells and subsequent muscle contractions. Consequently, it induces skeletal muscle paralysis, facilitating surgical procedures requiring muscle relaxation, aiding mechanical ventilation, or immobilizing patients during electroconvulsive therapy.
In addition to its clinical applications, Tubocurarine has also been a valuable tool in scientific research for studying the function of acetylcholine receptors and muscle physiology. It paved the way for the discovery and development of other, more selective neuromuscular blocking agents used in modern anesthesia.
Due to its limited therapeutic index and potential side effects, including hypotension and histamine release, d Tubocurarine has been mostly replaced by alternative drugs with better safety profiles and shorter durations of action. However, its historical significance in the field of anesthesia and its enduring impact on neuromuscular blockade research cannot be understated.
Common Misspellings for D TUBOCURARINE
- s tubocurarine
- x tubocurarine
- c tubocurarine
- f tubocurarine
- r tubocurarine
- e tubocurarine
- d rubocurarine
- d fubocurarine
- d gubocurarine
- d yubocurarine
- d 6ubocurarine
- d 5ubocurarine
- d tybocurarine
- d thbocurarine
- d tjbocurarine
- d tibocurarine
- d t8bocurarine
- d t7bocurarine
- d tuvocurarine
- d tunocurarine
Etymology of D TUBOCURARINE
The word "tubocurarine" is derived from multiple sources.
The term "tubo-" comes from the Latin word "tubus", which means "tube" or "pipe".
The word "curarine" is derived from "Curare", a term used by South American indigenous people, specifically the Caribs and Arawaks. Curare refers to the arrow poison used by these tribes for hunting.
Therefore, "tubocurarine" refers to a substance derived from a tube-like plant, Chondrodendron tomentosum, which is used as an arrow poison. It was later discovered that this substance had a paralyzing effect on muscles and was used as a muscle relaxant during surgery.
