D ASPARTYL L ISOASPARTYL METHYLTRANSFERASE Meaning and
Definition
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D-Aspartyl-L-Isoaspartyl Methyltransferase, also known as PCMT (protein L-isoaspartate O- methyltransferase), is an enzyme that plays a crucial role in repairing proteins damaged by the spontaneous deamidation or isomerization of aspartic acid residues in living organisms. It belongs to the methyltransferase family of enzymes and acts specifically on isoaspartyl residues.
The primary function of D-Aspartyl-L-Isoaspartyl Methyltransferase is to catalyze the methylation of L-isoaspartyl residues, converting them back into their normal conformation, L-aspartyl residues. This methylation process stabilizes the proteins structurally and functionally, preventing their degradation and facilitating their recognition and processing by the cellular machinery. The enzyme targets primarily cytoplasmic and nuclear proteins in mammalian cells and is present in various tissues and organs.
PCMT is a highly conserved enzyme and is found across diverse organisms, including bacteria, plants, and animals. Its activity is essential for protein repair and thus crucial for maintaining cellular homeostasis and preventing the accumulation of damaged proteins that could lead to various pathological conditions, such as neurodegenerative diseases.
Overall, D-Aspartyl-L-Isoaspartyl Methyltransferase is an enzyme involved in the maintenance and repair of damaged proteins, playing a vital role in cellular health and longevity. Its mechanistic action and functional significance make it an interesting target for therapeutic interventions aiming to ameliorate protein misfolding and aggregation-related diseases.
Common Misspellings for D ASPARTYL L ISOASPARTYL METHYLTRANSFERASE
- s aspartyl l isoaspartyl methyltransferase
- x aspartyl l isoaspartyl methyltransferase
- c aspartyl l isoaspartyl methyltransferase
- f aspartyl l isoaspartyl methyltransferase
- r aspartyl l isoaspartyl methyltransferase
- e aspartyl l isoaspartyl methyltransferase
- d zspartyl l isoaspartyl methyltransferase
- d sspartyl l isoaspartyl methyltransferase
- d wspartyl l isoaspartyl methyltransferase
- d qspartyl l isoaspartyl methyltransferase
- d aapartyl l isoaspartyl methyltransferase
- d azpartyl l isoaspartyl methyltransferase
- d axpartyl l isoaspartyl methyltransferase
- d adpartyl l isoaspartyl methyltransferase
- d aepartyl l isoaspartyl methyltransferase
- d awpartyl l isoaspartyl methyltransferase
- d asoartyl l isoaspartyl methyltransferase
- d aslartyl l isoaspartyl methyltransferase
- d as-artyl l isoaspartyl methyltransferase
- d as0artyl l isoaspartyl methyltransferase
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