How Do You Spell CYCLOSPORIN A?

Pronunciation: [sˈa͡ɪkləspˌɔːɹɪn ˈe͡ɪ] (IPA)

The correct spelling of the drug "Cyclosporin A" is often mispronounced due to its complex combination of sounds. In IPA phonetic transcription, it is spelled /saɪˌkloʊspəˈrɪn eɪ/. The "cy" is pronounced as "sai," followed by "clo" which is pronounced like "cloh." The "sporin" starts with an "sp" sound, followed by a blended "orin" sound. Finally, the "A" is pronounced as "ay." Proper pronunciation of drug names is crucial in healthcare settings to avoid confusion or medication errors.

CYCLOSPORIN A Meaning and Definition

1. Cyclosporin A, also known as CsA or Cs, is a powerful immunosuppressive drug that is primarily utilized in transplant medicine to prevent organ rejection in patients who have undergone organ transplantation. It is classified as a cyclic polypeptide and is derived from a natural compound produced by the fungus Tolypocladium inflatum.

   Cyclosporin A works by inhibiting the activity of T cells, a type of white blood cell that is crucial in the body's immune response. By suppressing T cell activation, CsA dampens the immune system's reaction to foreign tissue, thus preventing the rejection of transplanted organs.

   The drug is administered orally or intravenously, and it is well-absorbed in the gastrointestinal tract. It undergoes extensive metabolism in the liver, with only a small fraction excreted unchanged in the urine.

   Cyclosporin A can have several side effects, including elevated blood pressure, kidney dysfunction, increased susceptibility to infections, and neurotoxicity. Therefore, patients receiving CsA are regularly monitored to ensure their safety and to adjust the drug dosage if necessary.

   Beyond transplantation, cyclosporin A has also shown efficacy in the treatment of certain autoimmune diseases, such as severe psoriasis, rheumatoid arthritis, and atopic dermatitis. Additionally, it is used in ophthalmology to treat dry eye disease.

   Overall, cyclosporin A is an essential medication in the field of immunosuppression, playing a vital role in preventing organ rejection and managing various immune-related conditions.

Common Misspellings for CYCLOSPORIN A

• cyclosporjn a

Etymology of CYCLOSPORIN A

The word "Cyclosporin A" is derived from its chemical structure and the source from which it was isolated.

The term "cyclosporin" comes from "cyclo" meaning "ring" and "sporin" referring to its fungal origin. Cyclosporin is a compound produced by the fungus Tolypocladium inflatum, which was discovered in a soil sample from Norway in 1969 during a screening program for novel antifungal agents.

The "A" in "Cyclosporin A" denotes that it is the first variant of cyclosporin to be isolated. Cyclosporin A is the most widely studied and clinically used form of cyclosporin.

Similar spelling words for CYCLOSPORIN A

• Cyclosporine A,
• inhaled ciclosporin.