How Do You Spell CYCLOSPORIN?

Pronunciation: [sˈa͡ɪkləspˌɔːɹɪn] (IPA)

Cyclosporin is a medication commonly used to prevent organ rejection in transplant patients. The spelling of this word may seem confusing due to its unique combination of letters. However, the IPA phonetic transcription helps explain its pronunciation. The first syllable is pronounced as /saɪkloʊ/, which is similar to the word "cycle." The second and third syllables, /ˈspɔr ɪn/, sound like "spore" and "in." So, when combined, the word is pronounced as /saɪkloʊˈspɔrɪn/.

CYCLOSPORIN Meaning and Definition

1. Cyclosporin is a potent immunosuppressive drug widely used in medical practice to prevent the rejection of transplanted organs. It is a cyclic peptide consisting of 11 amino acids derived from the fungus Tolypocladium inflatum. The drug works by inhibiting the activation and proliferation of T-cells, which are responsible for immune responses in the body.

   Cyclosporin exerts its immunosuppressive effects through its interaction with cyclophilin, a protein found within T-cells. When bound to cyclophilin, cyclosporin forms a complex that inhibits the enzyme calcineurin. Calcineurin is crucial for the activation of T-cells, and its inhibition prevents the production of a key signaling molecule called interleukin-2. Without interleukin-2, T-cells cannot undergo clonal expansion and activation, which leads to a reduced immune response.

   This pharmacological mechanism makes cyclosporin extremely valuable in organ transplantation, as it helps prevent the rejection of transplanted organs by suppressing the immune system's response against non-self tissue. Additionally, cyclosporin has also been used in the treatment of various autoimmune disorders, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

   Although cyclosporin is highly effective in suppressing the immune response, it may have some adverse effects, including nephrotoxicity, hepatotoxicity, and an increased susceptibility to infections, due to the compromised immune system. Close monitoring of cyclosporin levels and careful observation of potential side effects are essential during treatment.

Common Misspellings for CYCLOSPORIN

• ciclosporiun
• xyclosporin
• vyclosporin
• fyclosporin
• dyclosporin
• ctclosporin
• cgclosporin
• c7closporin
• c6closporin
• cyxlosporin
• cyvlosporin
• cyflosporin
• cydlosporin
• cyckosporin
• cycposporin
• cycoosporin
• cyclisporin
• cyclksporin
• cycllsporin
• cyclpsporin

Etymology of CYCLOSPORIN

The word "Cyclosporin" is derived from two components: "cyclo-" and "-sporin".

1. "Cyclo-" comes from the Greek word "kyklos", meaning "circle" or "ring". In this context, it refers to the cyclic structure of the compound.

2. "-sporin" refers to a class of compounds derived from fungi. The suffix "-sporin" originates from "spore", which refers to the reproductive structure of fungi.

Combined, "Cyclosporin" refers to a cyclic compound derived from fungi.