CYCLIN D Meaning and
Definition
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Cyclin D is a protein molecule that plays a pivotal role in regulating the progression of the cell cycle. It functions as a key regulatory subunit of cyclin-dependent kinases (CDKs), which are enzyme complexes responsible for initiating various cellular processes. Cyclin D primarily affects the G1 phase of the cell cycle, which is the phase that precedes DNA synthesis.
The protein cyclin D binds to CDK4 and CDK6, forming active kinase complexes known as cyclin D-CDK4/6. These complexes act as catalytic subunits, phosphorylating specific target proteins and initiating the progression of the cell cycle through G1. It promotes the transition of the cell from the G1 phase to the S phase, where DNA replication occurs.
Cyclin D expression and activity are tightly regulated in normal cellular processes, as imbalances can have significant implications in cell proliferation and differentiation. Abnormal overexpression or dysregulation of cyclin D is often associated with the development of various malignancies, including breast, lung, and colon cancer.
Understanding cyclin D's role in the cell cycle and its regulation has led to the development of targeted therapies. Drugs that inhibit cyclin D synthesis or block its interaction with the CDK4/6 complex have shown promise as potential cancer treatments, particularly for tumors that exhibit dysregulated cyclin D expression.
Common Misspellings for CYCLIN D
- xyclin d
- vyclin d
- fyclin d
- dyclin d
- ctclin d
- cgclin d
- chclin d
- cuclin d
- c7clin d
- c6clin d
- cyxlin d
- cyvlin d
- cyflin d
- cydlin d
- cyckin d
- cycpin d
- cycoin d
- cyclun d
- cycljn d
- cyclkn d
Etymology of CYCLIN D
The word "Cyclin D" is derived from the combination of two components: "cyclin" and "D".
The term "cyclin" refers to a group of proteins involved in the cell cycle, which is the process by which a cell grows, duplicates its genetic material, and divides into two daughter cells. Cyclins activate specific enzymes called cyclin-dependent kinases (CDKs) at different stages of the cell cycle, regulating and coordinating its progression.
The letter "D" in Cyclin D represents a specific subtype or isoform of cyclin. In mammals, there are three types of cyclin D proteins known as Cyclin D1, D2, and D3. They play a crucial role in the progression from the G1 phase to the S phase of the cell cycle, where DNA replication occurs.
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