CYCLIN A Meaning and
Definition
-
Cyclin A is a type of protein that plays a crucial role in the regulation of the cell cycle, particularly during the S and G2 phases. It is a member of the cyclin protein family, which work in conjunction with cyclin-dependent kinases (CDKs) to control various aspects of cell division.
Cyclin A is synthesized and accumulates during the G1 phase, peaking in expression during the S phase. It then interacts with specific CDKs to form active complexes, known as cyclin A-CDK complexes, which subsequently phosphorylate target proteins involved in cell cycle progression. These phosphorylation events trigger critical events such as DNA replication, chromosome condensation, and cell cycle transition from G2 to mitosis.
Furthermore, cyclin A-CDK complexes also regulate the activity of cell cycle checkpoint proteins, contributing to the maintenance of genomic integrity and preventing abnormal cell division.
In addition to its role in cell cycle regulation, cyclin A has been implicated in other cellular processes, including transcriptional regulation, DNA repair, and apoptosis. It interacts with various other proteins, forming complexes that participate in these diverse functions.
Overall, cyclin A is a key player in orchestrating the orderly progression of the cell cycle, ensuring accurate DNA replication and cell division. Dysregulation of cyclin A expression or activity has been associated with several diseases, including cancer, highlighting its significance in maintaining proper cell growth and function.
Common Misspellings for CYCLIN A
- xyclin a
- vyclin a
- fyclin a
- dyclin a
- ctclin a
- cgclin a
- chclin a
- cuclin a
- c7clin a
- c6clin a
- cyxlin a
- cyvlin a
- cyflin a
- cydlin a
- cyckin a
- cycpin a
- cycoin a
- cyclun a
- cycljn a
- cyclkn a
Etymology of CYCLIN A
The word "Cyclin A" is derived from the term "cyclin" combined with the letter "A".
The term "cyclin" originates from the word "cycle", referring to the periodicity or cyclical nature of protein levels during the cell cycle. "Cyclin" was coined by R.A. Laskey and T. Hunt in 1979 to describe proteins that were observed to accumulate and disappear during different stages of the cell cycle. These proteins were found to play a crucial role in regulating cell division.
The letter "A" used in "Cyclin A" signifies a specific subtype or isoform of the cyclin protein family. Cyclins are classified into diverse types, including Cyclin A, Cyclin B, Cyclin C, etc. Each subtype has unique characteristics and functions during different stages of the cell cycle.
Infographic
Add the infographic to your website:
