CURARE Meaning and
Definition
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Curare refers to a potent and deadly toxin derived from several species of South American plants, typically belonging to the family Menispermaceae. It is primarily found in regions such as the Amazon rainforest and is commonly used by indigenous peoples as a hunting tool. The word "curare" is derived from the Carib language, in which it translates to "poison."
Curare acts as a potent neuromuscular blocking agent, causing paralysis by interfering with the normal transmission of nerve impulses at the neuromuscular junction. The primary mode of action involves blocking the action of acetylcholine, a neurotransmitter responsible for transmitting signals between nerve cells and muscles. By preventing acetylcholine from binding to its receptors on muscle cells, curare induces paralysis and can ultimately lead to respiratory failure if it reaches the muscles involved in breathing.
Due to its paralyzing effects, curare has been historically utilized as a valuable tool for indigenous tribes when hunting animals. By coating blow darts or arrowheads with curare, hunters can immobilize their prey without causing significant injury. However, it is important to note that the effects of curare can be life-threatening for humans when ingested or administered without proper medical supervision.
In modern medicine, curare and its derivatives, known as nondepolarizing neuromuscular blocking agents, find applications in anesthesia to facilitate intubation, muscle relaxation during surgical procedures, and mechanical ventilation. These drugs can be reversed with acetylcholinesterase inhibitors, such as neostigmine, to restore normal neuromuscular function.
Common Misspellings for CURARE
Etymology of CURARE
The word "curare" comes from the Cariban languages, specifically Arawak, which was spoken by the indigenous peoples in South America. The Carib word "wourali" or "urari" (which are variations of the same word) originally referred to the poisonous extract made from certain plants used for hunting and warfare. The word was borrowed into English and other languages as "curare" to describe this toxic substance.
Similar spelling words for CURARE
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