CREB KINASE Meaning and
Definition
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CREB kinase, also known as cAMP response element-binding protein (CREB) kinase, refers to a family of enzymes that play a crucial role in cellular signaling pathways and molecular processes involved in gene expression and protein synthesis. These kinases are responsible for the phosphorylation and subsequent activation of CREB, a transcription factor that regulates the transcription of numerous target genes.
CREB kinase comprises several members, including protein kinase A (PKA), protein kinase B (PKB, also known as Akt), and calcium/calmodulin-dependent protein kinase IV (CAMKIV). These kinases are activated by various extracellular signals, such as hormones, neurotransmitters, and growth factors, which stimulate intracellular signaling cascades ultimately leading to the activation of CREB kinase.
Upon activation, CREB kinase phosphorylates CREB at a specific serine residue, resulting in the recruitment of coactivator proteins and the formation of a transcriptional complex. This complex binds to specific DNA sequences known as cAMP response elements (CREs) in the promoter regions of target genes, promoting their transcription and subsequent translation into functional proteins.
The activation of CREB kinase and subsequent phosphorylation of CREB are involved in a wide range of biological processes, including learning and memory, neuronal development, synaptic plasticity, and cell survival. Dysregulation of CREB kinase signaling is also implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.
In summary, CREB kinase refers to a family of enzymes that regulate gene expression and protein synthesis by phosphorylating CREB, thereby modulating various cellular processes and playing crucial roles in normal physiology and disease.
Common Misspellings for CREB KINASE
- xreb kinase
- vreb kinase
- freb kinase
- dreb kinase
- ceeb kinase
- cdeb kinase
- cfeb kinase
- cteb kinase
- c5eb kinase
- c4eb kinase
- crwb kinase
- crsb kinase
- crdb kinase
- crrb kinase
- cr4b kinase
- cr3b kinase
- crev kinase
- cren kinase
- creh kinase
- creg kinase
Etymology of CREB KINASE
The word "CREB kinase" is a compound term combining the acronym "CREB" and the word "kinase".
"CREB" stands for cAMP response element-binding protein, which is a transcription factor involved in gene expression. The acronym was derived from the full name of the protein.
"Kinase", on the other hand, refers to an enzyme that catalyzes the transfer of a phosphate group from ATP to a specific substrate molecule. The term "kinase" comes from the Greek word "kinēsis", meaning motion or movement, and the suffix "-ase", denoting an enzyme.
Therefore, the etymology of "CREB kinase" lies in the combination of the acronym "CREB" and the term "kinase", highlighting the specific enzyme involved in the phosphorylation of CREB.
Similar spelling word for CREB KINASE
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