The "cone of Wulzen" refers to a gland located in the knee joints of some mammals. The spelling of this word is [kohn uhv wuhl-zuhn], according to the International Phonetic Alphabet (IPA). The "c" is pronounced as a "k", while the "o" is pronounced as "ah". The "e" at the end of "cone" is silent, and the "w" in "Wulzen" is pronounced like a "v". This gland is named after its discoverer, Rima Laibow, who was formerly known as Rima E. Laibow-Wulzen.
The "cone of Wulzen" refers to a specialized structure found in the body called the Wulzen gland, located in the knee joint of various mammals, including cows and pigs. It is named after the scientist, R. Wulzen, who first identified this gland and its function. This cone-shaped gland consists mainly of connective tissue and is situated within the synovial membrane - the thin, flexible tissue lining the joint cavities.
The cone of Wulzen is involved in the production of a substance called the "anti-stiffness factor" or "Wulzen factor." This factor is a heat-stable fatty acid called cetyl-myristoleate, which acts as a natural lubricant for the joints, preventing stiffness and maintaining their smooth articulation during movement. It is believed to possess anti-inflammatory properties and may also contribute to reducing pain associated with joint conditions such as osteoarthritis.
Although the cone of Wulzen is present in many mammals, including humans, its functionality and the production of the anti-stiffness factor appear to be limited or absent in certain individuals and breeds. This may explain why some individuals are more prone to joint stiffness and related conditions.
Due to its potential therapeutic value, cetyl-myristoleate derived from the cone of Wulzen has been extensively studied in the field of joint health and could offer alternative treatments for joint-related disorders.