Cilastatin Monosodium Salt is a pharmaceutical compound used in combination with certain antibiotics to enhance their therapeutic effects in the treatment of severe bacterial infections. It is commonly used alongside the antibiotic imipenem as a dual medication known as imipenem/cilastatin.
Cilastatin Monosodium Salt works by inhibiting the enzyme dehydropeptidase-1, which is responsible for breaking down imipenem in the kidneys. By preventing this breakdown, cilastatin allows imipenem to remain active in the body for a longer duration, thereby increasing its efficacy against a wide range of susceptible bacteria.
This compound is administered intravenously and is mainly used in hospital settings for the treatment of complex infections such as intra-abdominal infections, pneumonia, urinary tract infections, and complicated skin and soft tissue infections.
Cilastatin Monosodium Salt is generally well-tolerated, but like other medications, it may cause side effects such as rash, diarrhea, nausea, vomiting, and allergic reactions. It is important to inform healthcare professionals about any history of allergies or kidney diseases before starting treatment with this medication.
Overall, Cilastatin Monosodium Salt is an essential adjunct therapy that maximizes the effectiveness of imipenem in treating severe bacterial infections, ensuring better patient outcomes and reducing the development of antibiotic resistance.
