Chronic Progressive Chorea (CPC) is a neurodegenerative disorder that primarily affects the basal ganglia, a group of structures located deep in the brain. It is characterized by involuntary, purposeless, and random movements, also known as chorea. These movements tend to worsen over time and can spread to different parts of the body.
The term "chronic" indicates that the condition develops slowly and progresses gradually over an extended period. The word "progressive" emphasizes the nature of the disorder, as symptoms tend to worsen over time. Chorea refers to the characteristic jerky, dance-like movements that are a hallmark of the condition.
CPC is typically caused by an inherited genetic mutation, with the most common form being Huntington's disease. This mutation affects a protein called huntingtin, leading to the death of neurons in the brain. The loss of these neurons disrupts normal movement control and coordination, resulting in the involuntary choreic movements associated with CPC.
Aside from chorea, individuals with CPC may also experience other symptoms, including impaired balance, difficulties with voluntary movements, cognitive decline, and psychiatric symptoms such as depression or irritability. As the condition progresses, individuals may experience worsening motor and cognitive dysfunction, compromising their ability to carry out daily activities.
Although there is currently no cure for CPC, symptoms can be managed through various treatment approaches, such as medication to control movement, physical therapy to improve mobility and muscle strength, and supportive care to address psychiatric and cognitive symptoms.
