CHOLERETICS AND CHOLAGOGUES Meaning and
Definition
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Choleretics and cholagogues are two distinct categories of drugs or substances that affect the production or flow of bile in the human body.
Choleretics are substances that promote the production or secretion of bile from the liver. Bile is a yellowish-green fluid produced by the liver that aids in the digestion and absorption of fats. Choleretics stimulate the liver to produce and release more bile into the small intestine, where it emulsifies fats and aids in their absorption by breaking them down into smaller particles. These substances are often used therapeutically to increase bile flow in individuals with conditions such as cholestasis, where the flow of bile is obstructed or limited. Choleretics can include natural compounds, such as specific herbs or plant extracts like artichoke or turmeric, or synthetic medications that have bile-promoting effects.
On the other hand, cholagogues are substances that stimulate the contraction of the gallbladder, which releases stored bile into the small intestine. The gallbladder is a small organ located under the liver that stores bile between meals until it is needed for digestion. Cholagogues prompt the gallbladder to contract, facilitating the release of stored bile and promoting its flow into the intestine. This category of substances is often employed to relieve symptoms associated with gallbladder disorders or to support the digestion of fatty foods. Cholagogues can be natural, like dandelion or barberry, or synthetic medications specifically formulated to stimulate gallbladder contractions.
Overall, both choleretics and cholagogues have important roles in maintaining proper bile production and flow, which are essential for effective digestion and nutrient absorption.
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