CHO cells are a type of mammalian cell line widely used in biotechnology and pharmacology research. The spelling of CHO is an abbreviation for Chinese Hamster Ovary, which represents the origin of these cells. The pronunciation of CHO is /tʃiː-əʊ/ with two distinct sounds (/tʃ/ and /iː/) and the final sound pronounced as a diphthong (/əʊ/). The word "cells" is pronounced /sɛlz/. Together, CHO cells are pronounced as /tʃiː-əʊ sɛlz/. The correct spelling and pronunciation are crucial, especially in scientific communication.
CHO cells, short for Chinese hamster ovary cells, are a type of mammalian cell line derived from the ovaries of Chinese hamsters (Cricetulus griseus). These cells have become a commonly used model system in biotechnology and molecular biology due to their ability to efficiently produce recombinant proteins.
CHO cells are ideal for industrial applications such as the production of therapeutic proteins, vaccines, and monoclonal antibodies. They have been extensively engineered and optimized for high productivity and growth rates. These cells offer numerous advantages, including stability, scalability, and ease of genetic modification.
The CHO cell line possesses various features that contribute to their suitability for industrial usage. They are known to have a high capacity to produce complex recombinant proteins, and they exhibit proper protein folding and post-translational modifications similar to human cells. CHO cells are also able to survive in suspension culture, making them suitable for large-scale bioreactor cultivation.
Researchers can genetically modify CHO cells by introducing specific genes or altering their genetic makeup for desired product expression. This enables the production of recombinant proteins with specific characteristics, such as increased yield, improved stability, or optimized glycosylation patterns.
In summary, CHO cells are a widely utilized mammalian cell line due to their ability to efficiently express and produce recombinant proteins. They offer stability, scalability, and ease of genetic modification, making them a valuable tool in biotechnology and molecular biology research.
The word "CHO Cells" stands for Chinese Hamster Ovary Cells. The term originates from the source of these cells, which are derived from the ovary tissues of Chinese hamsters. These cells were popularized for use in biological and biotechnological research due to their ability to grow easily in a laboratory setting and their usefulness in producing therapeutic proteins. Therefore, the acronym "CHO" was derived to represent these particular cells.