The CHO Cell is a cell line commonly used in biotechnology and research. The spelling of "CHO" is not intuitive as it is an abbreviation for "Chinese hamster ovary," but it is pronounced /tʃoʊ/ phonetically. The "ch" is pronounced as the "ch" in "choose," followed by the "o" sound in "no," and ending with the "long o" sound in "go." This pronunciation can be confusing for those unfamiliar with the term, but it is important to use the correct spelling and phonetic transcription to accurately communicate in scientific fields.
CHO cell is an acronym for Chinese Hamster Ovary cell, a widely used mammalian cell line in biotechnology and pharmaceutical industries. These cells are derived from the ovary of the Chinese hamster, Cricetulus griseus. CHO cells have become extensively popular due to their ability to produce recombinant protein products and their advantageous attributes for large-scale manufacturing processes.
The CHO cell line is notable for its high growth rate, robustness, adaptability to various culture conditions, and the capability to produce complex proteins with post-translational modifications. These cells are particularly advantageous for the production of therapeutic proteins, including monoclonal antibodies, hormones, and viral vaccines, due to their ability to closely resemble human-like protein production.
CHO cells are commonly used to establish cell cultures for biopharmaceutical research and production. In laboratory settings, these cells are manipulated using genetic engineering techniques to stably express a specific gene of interest, thus enabling the production of recombinant proteins. CHO cells are capable of efficient protein production and can be grown in suspension or adherent cultures, making them versatile options for scale-up production in biomanufacturing.
Due to their wide applications and successful track record, CHO cells have become the cell line of choice for researchers and developers in the biotechnology field. Their versatility and compatibility with different production processes have solidified their reputation as an indispensable tool in the manufacturing of therapeutic proteins.
The word "CHO cell" is derived from the name of the Chinese hamster ovary (CHO) cells. "CHO" refers to the specific species of hamster from which these cells were first isolated and cultured in the laboratory for research purposes. These cells were first derived from an ovarian tissue sample of a female Chinese hamster back in the 1960s. Over time, CHO cells have become widely used in biotechnology and pharmaceutical industries for the production of various recombinant therapeutic proteins, antibodies, and vaccines. The acronym "CHO" has thus become associated with these specific cells and is commonly used in scientific terminology.