CALYCULIN A Meaning and
Definition
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Calyculin A is a potent, naturally occurring marine toxin that belongs to the group of cyclic peptide polyketides. It was originally isolated from the sponge Discodermia calyx and is known for its strong inhibitory effect on the activity of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), which are essential enzymes involved in cellular signaling and regulation.
Calyculin A acts as a reversible inhibitor of PP1 and PP2A by binding to their catalytic subunits, thus interfering with their ability to dephosphorylate target proteins. This leads to a disruption in various cellular processes, including cell cycle progression, protein synthesis, and gene expression.
Due to its inhibition of protein phosphatases, calyculin A has become an invaluable tool in scientific research to investigate signal transduction pathways and explore the roles of protein phosphorylation in various cellular functions. It has been particularly useful in studying the regulation of mitogen-activated protein kinases (MAPKs) and cyclin-dependent kinases (CDKs), which are critical for cell growth, proliferation, and differentiation.
Calyculin A is considered a highly potent and selective inhibitor, and its use has expanded our understanding of cellular signaling pathways and provided insights into disease mechanisms. However, due to its potent nature, calyculin A must be handled and used with caution in laboratory settings.
Common Misspellings for CALYCULIN A
- xalyculin a
- valyculin a
- falyculin a
- dalyculin a
- czlyculin a
- cslyculin a
- cwlyculin a
- cqlyculin a
- cakyculin a
- capyculin a
- caoyculin a
- caltculin a
- calgculin a
- calhculin a
- caluculin a
- cal7culin a
- cal6culin a
- calyxulin a
- calyvulin a
- calyfulin a
Etymology of CALYCULIN A
The word "calyculin A" is derived from scientific nomenclature.
The term "calyculin" originates from the plant genus "Calycula", which belongs to the family Thymelaeaceae. Calyculin A is a secondary metabolite extracted from the marine sponge Discodermia calyx. It was first isolated and identified by the Japanese scientist Shigeki König in 1988.
The suffix "A" is commonly used in organic chemistry to differentiate between different structurally similar compounds within a specific group or family. In this case, "calyculin A" specifically refers to the first discovered and most well-known analog of calyculin.
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