C-Ki-ras genes, also known as Kirsten rat sarcoma viral oncogene homolog, refer to a family of genes that encode proteins involved in cell signaling and regulation of cell growth. These genes are part of the Ras signaling pathway, which plays a crucial role in controlling various cellular processes such as proliferation, differentiation, and survival.
C-Ki-ras genes belong to the larger Ras gene family, which consists of three paralogs: Harvey rat sarcoma viral oncogene homolog (H-Ras), Neuroblastoma Ras viral oncogene homolog (N-Ras), and Kirsten rat sarcoma viral oncogene homolog (K-Ras). Among these, K-Ras is the most commonly studied and understood.
Mutations in c-Ki-ras genes are frequently associated with several types of cancer, particularly in the pancreas, lungs, and colorectal tissues. These gene mutations result in the production of aberrant proteins that lead to dysregulated cell growth and increased resistance to apoptosis, contributing to tumor formation and progression.
Due to their significance in cancer development, c-Ki-ras genes have become targets for therapeutic interventions. Researchers have focused on developing drugs that specifically target mutant K-Ras proteins to inhibit their oncogenic activity and potentially halt tumor growth.
In summary, c-Ki-ras genes are an important subset of the Ras gene family, involved in regulating cell growth and signaling. Mutations in these genes are commonly found in various cancers and represent potential therapeutic targets in cancer treatment.
