Aspartate aminotransferase is an enzyme that plays an essential role in amino acid metabolism. The spelling of this word can be a bit tricky because of its different sound patterns. The word "aspartate" is pronounced /æsˈpɑrteɪt/ (as-PAR-tayt) with the stress on the second syllable. The word "aminotransferase" is pronounced /ˌeɪmɪnoʊtrænsˈfɜrˌeɪz/ (a-MEE-noh-trans-FER-ayz) with the stress on the third syllable. Although it may be challenging to spell, understanding the phonetic transcription of this word can help healthcare professionals accurately communicate and understand each other.
Aspartate Aminotransferase, commonly known as AST, is an enzyme found in various tissues of the human body, particularly in the liver, heart, skeletal muscles, and kidneys. It plays a crucial role in the metabolism of amino acids, specifically the conversion of aspartate to oxaloacetate.
AST is classified as a transaminase enzyme, as it facilitates the transfer of an amino group from aspartate to a keto acid, resulting in the creation of oxaloacetate and glutamate. This enzymatic reaction is reversible and essential for several metabolic processes, including the synthesis of non-essential amino acids.
Due to its widespread distribution in the body, AST levels are often used as a diagnostic marker for assessing the health of various organs, particularly the liver and heart. Elevated levels of AST in the bloodstream typically indicate tissue damage or injury to these organs. However, it is important to note that AST elevation alone cannot diagnose a specific medical condition, as other factors must be considered.
AST levels are measured through a blood test, and the normal range may vary depending on age, gender, and laboratory reference values. Abnormal AST levels can be associated with a variety of liver disorders, such as hepatitis, cirrhosis, or liver damage caused by alcohol abuse or medication. Additionally, heart conditions like myocardial infarction (heart attack) or congestive heart failure may also result in elevated AST levels.
In summary, aspartate aminotransferase is an enzyme involved in amino acid metabolism that serves as a marker for liver and heart health when detected in the bloodstream.
The word "Aspartate Aminotransferase" has its roots in the Latin and Greek languages.
The term "aspartate" is derived from the Latin word "asparaginum" which means "asparagus". It comes from the fact that asparaginum was first isolated from asparagus juice.
"Aminotransferase" is a combination of the Latin word "amino" which means "related to amino acids" and the Greek word "transferase" which means "transfer". It is used to refer to enzymes that transfer an amino group from one molecule to another.
Therefore, "Aspartate Aminotransferase" refers to an enzyme that transfers an amino group from aspartate to another molecule.