How Do You Spell ARGININOSUCCINASE?

Pronunciation: [ˈɑːd͡ʒɪnˌɪnəsəksˌɪne͡ɪs] (IPA)

Argininosuccinase is a challenging word to spell due to its complex phonemes. It is pronounced as /ɑːˌdʒɪnɪnoʊˈsʌkeɪs/, where the first sound /ɑː/ is similar to the "a" in "car". The IPA phonetic transcription of this word enables one to comprehend its spelling rules, which includes subtle tonal variations and stress. For better pronunciation, one should carefully note the sound of the letter ‘g,’ which has a subtle tone, as well as the placement of the stress in the middle of the word, on ‘-ino-’.

ARGININOSUCCINASE Meaning and Definition

1. Argininosuccinase is an enzyme that plays a crucial role in the urea cycle, a metabolic pathway that takes place in the liver and converts toxic ammonia into urea for excretion. It is encoded by the ASL gene in humans and is also known as argininosuccinate lyase or argininosuccinate cleavage enzyme.

   The primary function of argininosuccinase is to cleave argininosuccinate, a molecule formed from the condensation of citrulline and aspartate. This enzymatic reaction yields arginine and fumarate, which can then be further metabolized in the urea cycle. In essence, argininosuccinase acts as a catalyst, breaking down argininosuccinate into its constituent components.

   A deficiency in argininosuccinase results in argininosuccinic aciduria, an inborn error of metabolism characterized by the accumulation of argininosuccinate and its subsequent excretion in urine. This condition may lead to hyperammonemia, a high level of ammonia in the blood, which can cause severe neurological symptoms and potentially be life-threatening.

   Research has shown that argininosuccinase is highly conserved among various organisms, including bacteria, yeast, plants, and mammals. Its evolutionary significance lies in the crucial role it plays in nitrogen metabolism and its ability to maintain the body's nitrogen balance.

   In summary, argininosuccinase is an essential enzyme in the urea cycle, responsible for catalyzing the cleavage of argininosuccinate into arginine and fumarate. Its deficiency can lead to argininosuccinic aciduria and hyperammonemia, highlighting its vital role in maintaining proper nitrogen metabolism.

Common Misspellings for ARGININOSUCCINASE

• zrgininosuccinase
• srgininosuccinase
• wrgininosuccinase
• qrgininosuccinase
• aegininosuccinase
• adgininosuccinase
• afgininosuccinase
• atgininosuccinase
• a5gininosuccinase
• a4gininosuccinase
• arfininosuccinase
• arvininosuccinase
• arbininosuccinase
• arhininosuccinase
• aryininosuccinase
• artininosuccinase
• arguninosuccinase
• argjninosuccinase
• argkninosuccinase
• argoninosuccinase

Etymology of ARGININOSUCCINASE

The word "Argininosuccinase" is derived from the combination of two main components: "arginino" and "succinase".

1. "Arginino" is derived from the chemical compound "arginine". Arginine is an amino acid that plays a vital role in protein synthesis and is found in various food sources. The term "arginino" indicates that the word is related to or derived from arginine.

2. "Succinase" is derived from the term "succinic acid". Succinic acid is a dicarboxylic acid that is part of the citric acid cycle, also known as the Krebs cycle. The term "succinase" indicates that the word is related to or derived from succinic acid.

When combined, "arginino" and "succinase" create the word "Argininosuccinase".