ARACHIDONATE LIPOXYGENASES Meaning and
Definition
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Arachidonate lipoxygenases are a group of enzymes that play a crucial role in the metabolism of arachidonic acid, a fatty acid found in cell membranes. These enzymes are part of the lipoxygenase family, which are responsible for the oxygenation of polyunsaturated fatty acids.
Arachidonate lipoxygenases specifically catalyze the conversion of arachidonic acid into various biologically active compounds. This enzymatic reaction involves the insertion of molecular oxygen into a specific carbon-carbon double bond of arachidonic acid, resulting in the formation of hydroperoxide products.
There are several isoforms of arachidonate lipoxygenases, including 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase. Each isoform has unique substrate specificity and tissue distribution, leading to the production of different lipid mediators with diverse biological activities.
The products generated by arachidonate lipoxygenases serve as important signaling molecules in various physiological and pathophysiological processes. For example, the 5-lipoxygenase pathway produces leukotrienes, which are potent mediators of inflammation and immune responses. In contrast, the 15-lipoxygenase pathway generates lipoxins and resolvins, which possess anti-inflammatory and pro-resolving actions.
Overall, arachidonate lipoxygenases are critical regulators of lipid signaling pathways and have significant implications in various biological processes, including inflammation, immune responses, and the maintenance of tissue homeostasis. Understanding the functions and mechanisms of these enzymes can aid in the development of therapeutic interventions for diseases associated with dysregulated lipid metabolism.
Common Misspellings for ARACHIDONATE LIPOXYGENASES
- zrachidonate lipoxygenases
- srachidonate lipoxygenases
- wrachidonate lipoxygenases
- qrachidonate lipoxygenases
- aeachidonate lipoxygenases
- adachidonate lipoxygenases
- afachidonate lipoxygenases
- atachidonate lipoxygenases
- a5achidonate lipoxygenases
- a4achidonate lipoxygenases
- arzchidonate lipoxygenases
- arschidonate lipoxygenases
- arwchidonate lipoxygenases
- arqchidonate lipoxygenases
- araxhidonate lipoxygenases
- aravhidonate lipoxygenases
- arafhidonate lipoxygenases
- aradhidonate lipoxygenases
- aracgidonate lipoxygenases
- aracbidonate lipoxygenases
Etymology of ARACHIDONATE LIPOXYGENASES
The word "arachidonate" comes from "arachidonic acid", which is a polyunsaturated fatty acid found in the phospholipids of cell membranes. "Arachidonic acid" itself is named after the oil extracted from the peanut, which is commonly known as "arachis oil".
"Lipoxygenases" is a term coined from "lipo" (meaning fat) and "oxygenase" (an enzyme that adds oxygen to a substance). "Lipoxygenases" refers to a family of enzymes that insert molecular oxygen into polyunsaturated fatty acids, such as arachidonic acid.
Therefore, "arachidonate lipoxygenases" refers to the enzymes that catalyze the oxygenation of arachidonic acid and/or its derivatives.
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